| pubmed-article:14508078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0442592 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0022877 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C1333196 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C1366521 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C1149234 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:14508078 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:14508078 | pubmed:issue | 4 Suppl 1 | lld:pubmed |
| pubmed-article:14508078 | pubmed:dateCreated | 2003-9-25 | lld:pubmed |
| pubmed-article:14508078 | pubmed:abstractText | An obstacle to effective gene-based cancer therapies is the limited number of cancer-specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction subtraction hybridization (DISH) approach with human melanoma cells, melanoma differentiation associated (mda) genes were isolated that display elevated expression as a function of irreversible growth arrest, cancer reversion and terminal differentiation. This screening paradigm resulted in the cloning of mda-7 in the context of terminal differentiation of human melanoma cells. Based on its structure, chromosomal location, sequence homology and cytokine-like properties, mda-7 has now been renamed IL-24 and classified as a member of the expanding IL-10 cytokine gene family. Expression of mda-7/IL-24 inversely correlates with melanoma progression and administration of mda-7/IL-24 by means of a replication incompetent adenovirus, Ad.mda-7, results in growth suppression and apoptosis in melanoma cells as well as in a broad-spectrum of additional cancer cell types. In contrast, Ad.mda-7 does not elicit deleterious effects in normal cells, including those of epithelial, fibroblast, astrocyte, melanocyte or endothelial origin. Based on these distinctive properties and anti-tumor and anti-angiogenic activities in human tumor xenograft animal models, mda-7/IL-24 has now entered the clinical arena. A Phase I/II clinical trial in patients with advanced carcinomas involving intratumoral administration of mda-7/IL-24 [using a replication incompetent adenovirus; ING241 (Ad.mda-7)] has documented that this gene is safe and well tolerated by patients and a single virus injection elicits apoptosis in a majority of the tumor. Current data suggests that mda-7/IL-24 may function as a dual-acting cytokine in which its normal physiological functions may be related to specific aspects of the immune system and over-expression culminates in cancer-specific apoptosis. This review will provide a prospectus of our current understanding of mda-7/IL-24. | lld:pubmed |
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| pubmed-article:14508078 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14508078 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14508078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14508078 | pubmed:issn | 1538-4047 | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:DentPaulP | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:CurielDavid... | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:Gopalkrishnan... | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:FisherPaul... | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:ChadaSunilS | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:GrimmElizabet... | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:RameshRajagop... | lld:pubmed |
| pubmed-article:14508078 | pubmed:author | pubmed-author:RosenfeldMyrn... | lld:pubmed |
| pubmed-article:14508078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14508078 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:14508078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14508078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14508078 | pubmed:pagination | S23-37 | lld:pubmed |
| pubmed-article:14508078 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:14508078 | pubmed:articleTitle | mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic. | lld:pubmed |
| pubmed-article:14508078 | pubmed:affiliation | Departments of Pathology, Neurosurgery and Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons; New York, New York 1032, USA. pbf1@columbia.edu | lld:pubmed |
| pubmed-article:14508078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14508078 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14508078 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:14508078 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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