| pubmed-article:14507655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14507655 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14507655 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:14507655 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:14507655 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:14507655 | lifeskim:mentions | umls-concept:C1706907 | lld:lifeskim |
| pubmed-article:14507655 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14507655 | pubmed:dateCreated | 2003-9-25 | lld:pubmed |
| pubmed-article:14507655 | pubmed:abstractText | Although a number of autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmune lesions remain unclear. We speculate that antiestrogenic actions might be a potent factor in the formation of pathogenic autoantigens. Previously, we have identified 120-kd alpha-fodrin as an important autoantigen in Sjögren's syndrome (SS). When healthy C57BL/6 (B6) mice were treated with an ovariectomy (Ovx), we found a significant increase in TUNEL(+)-apoptotic epithelial cells in the salivary gland cells associated with alpha-fodrin cleavage during 2 and 3 weeks after Ovx. By contrast, no apoptotic cells were found in estrogen receptor-alpha knockout mice. In in vitro studies using primary cultured mouse salivary gland cells and human salivary gland cells, we found a cleavage product of 120-kd alpha-fodrin in cells that had undergone tamoxifen (Tam)-induced apoptosis through caspase activation, especially caspase-1. Adoptive transfer of alpha-fodrin-reactive T cells into Ovx-B6 and -SCID mice resulted in the development of autoimmune exocrinopathy quite similar to SS. These results suggest that estrogen deficiency exerts a crucial influence on autoantigen cleavage, and may cause, in part, autoimmune exocrinopathy in postmenopausal women. | lld:pubmed |
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| pubmed-article:14507655 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14507655 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14507655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14507655 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14507655 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:HayashiYoshio... | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:IshimaruNaozu... | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:ArakakiRiekoR | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:KobayashiMasa... | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:WatanabeMegum... | lld:pubmed |
| pubmed-article:14507655 | pubmed:author | pubmed-author:MiyazakiKatsu... | lld:pubmed |
| pubmed-article:14507655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14507655 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:14507655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14507655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14507655 | pubmed:pagination | 1481-90 | lld:pubmed |
| pubmed-article:14507655 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:14507655 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14507655 | pubmed:articleTitle | Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background. | lld:pubmed |
