| pubmed-article:14505681 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14505681 | lifeskim:mentions | umls-concept:C1421467 | lld:lifeskim |
| pubmed-article:14505681 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:14505681 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:14505681 | pubmed:dateCreated | 2003-9-24 | lld:pubmed |
| pubmed-article:14505681 | pubmed:abstractText | A series of 4-(2-pyridyl)piperazine-1-carboxamide analogues based on the lead compound 1 was synthesized and evaluated for VR1 antagonist activity in capsaicin-induced (CAP) and pH (5.5)-induced (pH) FLIPR assays in a rat VR1-expressing HEK293 cell line. Potent VR1 antagonists were identified through SAR studies. From these studies, 18 was found to be very potent in the in vitro assay [IC(50)=4.8 nM (pH) and 35 nM (CAP)] and orally available in rat (F%=15.1). | lld:pubmed |
| pubmed-article:14505681 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14505681 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14505681 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14505681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14505681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14505681 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14505681 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14505681 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:SunQunQ | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:KyleDonald... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:ValenzanoKenn... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:ZhouXiaomingX | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:ZhangChongwuC | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:RotshteynYako... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:HachichaMoham... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:TafesseLaykea... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:IslamKhondake... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:VictorySam... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:SchmidLori... | lld:pubmed |
| pubmed-article:14505681 | pubmed:author | pubmed-author:PatelAniketA | lld:pubmed |
| pubmed-article:14505681 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14505681 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:14505681 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:14505681 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14505681 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14505681 | pubmed:pagination | 3611-6 | lld:pubmed |
| pubmed-article:14505681 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:meshHeading | pubmed-meshheading:14505681... | lld:pubmed |
| pubmed-article:14505681 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14505681 | pubmed:articleTitle | 4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists. | lld:pubmed |
| pubmed-article:14505681 | pubmed:affiliation | Purdue Pharma L.P., 6 Cedar Brook Drive, Cranbury, NJ 08512, USA. qun.sun@pharma.com | lld:pubmed |
| pubmed-article:14505681 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:14505681 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:14505681 | lld:pubmed |
