Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1438574rdf:typepubmed:Citationlld:pubmed
pubmed-article:1438574lifeskim:mentionsumls-concept:C0034721lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C0017638lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C0031740lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C0184511lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C0038952lld:lifeskim
pubmed-article:1438574lifeskim:mentionsumls-concept:C1298613lld:lifeskim
pubmed-article:1438574pubmed:issue3lld:pubmed
pubmed-article:1438574pubmed:dateCreated1992-12-14lld:pubmed
pubmed-article:1438574pubmed:abstractTextThe effectiveness of intratumoral photoradiation in photodynamic therapy (PDT) using a polyporphyrin photosensitizer was studied in the RT-2 rat glioma model. One week after intracerebral implantation of RT-2 cells, experimental rats received a single i.p. injection of 2 mg/kg of Photofrin. After administration of the photosensitizer (48 h), the tumors were partially resected and the exposed cavity was irradiated with 15 J of laser light at a wavelength of 630 nm. Further treatment with a large craniectomy significantly enhanced rat survival. Control rats which received no photosensitizer but were treated with surgery, alone or in combination with laser irradiation, succumbed from early tumor recurrence. Photodynamic therapy without decompressive surgery resulted in hemorrhagic infarction of residual tumor and adjacent brain with focal cerebral edema which resulted in cerebral herniation and early death. Our results indicate that photodynamic therapy is effective in treating residual brain tumor but at the expense of brain tissue surrounding the tumor. Unless relieved, intracranial pressure from photodynamic therapy-associated cerebral edema in this animal model resulted in shortened survival.lld:pubmed
pubmed-article:1438574pubmed:languageenglld:pubmed
pubmed-article:1438574pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1438574pubmed:citationSubsetIMlld:pubmed
pubmed-article:1438574pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1438574pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1438574pubmed:statusMEDLINElld:pubmed
pubmed-article:1438574pubmed:monthSeplld:pubmed
pubmed-article:1438574pubmed:issn0031-8655lld:pubmed
pubmed-article:1438574pubmed:authorpubmed-author:BrownJ TJTlld:pubmed
pubmed-article:1438574pubmed:authorpubmed-author:JOCClld:pubmed
pubmed-article:1438574pubmed:authorpubmed-author:PowersS KSKlld:pubmed
pubmed-article:1438574pubmed:authorpubmed-author:WalstadDDlld:pubmed
pubmed-article:1438574pubmed:issnTypePrintlld:pubmed
pubmed-article:1438574pubmed:volume56lld:pubmed
pubmed-article:1438574pubmed:ownerNLMlld:pubmed
pubmed-article:1438574pubmed:authorsCompleteYlld:pubmed
pubmed-article:1438574pubmed:pagination385-90lld:pubmed
pubmed-article:1438574pubmed:dateRevised2003-11-14lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:meshHeadingpubmed-meshheading:1438574-...lld:pubmed
pubmed-article:1438574pubmed:year1992lld:pubmed
pubmed-article:1438574pubmed:articleTitleImproved survival from intracavitary photodynamic therapy of rat glioma.lld:pubmed
pubmed-article:1438574pubmed:affiliationDivision of Neurosurgery, University of North Carolina, Chapel Hill 27599-7060.lld:pubmed
pubmed-article:1438574pubmed:publicationTypeJournal Articlelld:pubmed