| pubmed-article:1438267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C0009498 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:1438267 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:1438267 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:1438267 | pubmed:dateCreated | 1992-12-23 | lld:pubmed |
| pubmed-article:1438267 | pubmed:abstractText | Slp (sex-limited protein) is a mouse serum protein encoded by a major histocompatibility complex class III gene. It is considered to be a product of a duplicated complement component C4 gene, but without functional activity. Originally it has been found expressed only in adult males with the S region of the H-2d or H-2s haplotype. In this report we present evidence that Slp is involved in a form of mouse complement activation that occurs after fractionation of serum by polyethylene glycol precipitation. This activation pathway is EDTA-resistant (i.e., independent of classical and alternative pathway activation), is regulated by C1 inhibitor, and leads to the generation of hemolytically active membrane attack complexes. A positive correlation between this EDTA-resistant mouse complement activity and reported Slp levels was found. Direct evidence for a functional role of Slp came from substitution experiments in which purified Slp induced hemolytic activity in polyethylene glycol-fractionated, Slp-deficient mouse serum. Selective depletion of other complement components suggested a role for C1s-, C2, and C5, but not C3, in the Slp-dependent complement activation. A model for this type of mouse complement activation is presented. | lld:pubmed |
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| pubmed-article:1438267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1438267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1438267 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1438267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1438267 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1438267 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1438267 | pubmed:author | pubmed-author:DémantPP | lld:pubmed |
| pubmed-article:1438267 | pubmed:author | pubmed-author:Van DijkHH | lld:pubmed |
| pubmed-article:1438267 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:1438267 | pubmed:author | pubmed-author:AertsP CPC | lld:pubmed |
| pubmed-article:1438267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1438267 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1438267 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1438267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1438267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1438267 | pubmed:pagination | 10711-5 | lld:pubmed |
| pubmed-article:1438267 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1438267 | pubmed:meshHeading | pubmed-meshheading:1438267-... | lld:pubmed |
| pubmed-article:1438267 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1438267 | pubmed:articleTitle | Slp is an essential component of an EDTA-resistant activation pathway of mouse complement. | lld:pubmed |
| pubmed-article:1438267 | pubmed:affiliation | Eijkman-Winkler Institute for Medical and Clinical Microbiology, Utrecht University, Faculty of Medicine, University Hospital, The Netherlands. | lld:pubmed |
| pubmed-article:1438267 | pubmed:publicationType | Journal Article | lld:pubmed |
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