Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1436401rdf:typepubmed:Citationlld:pubmed
pubmed-article:1436401lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C0521329lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C0026833lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C0597502lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C1883254lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C0441712lld:lifeskim
pubmed-article:1436401lifeskim:mentionsumls-concept:C0174091lld:lifeskim
pubmed-article:1436401pubmed:issue9lld:pubmed
pubmed-article:1436401pubmed:dateCreated1992-11-27lld:pubmed
pubmed-article:1436401pubmed:abstractTextThe mechanisms of the depressant action of (R)-4-chloro-2-(2-hydroxy-3-morpholinopropyl)-5-phenyl-4-isoxaz olin-3-one hydrochloride (CS-722), a newly synthesized centrally acting muscle relaxant, on spinal reflexes were investigated in spinal rats. The drug CS-722 (50 mg/kg, i.v.) depressed the polysynaptic reflex but was less effective on the monosynaptic reflex. Eperisone-HCl (10 mg/kg, i.v.) and baclofen (2 mg/kg, i.v.) markedly decreased the monosynaptic and polysynaptic reflexes, with longer durations than CS-722; CS-722, eperisone and baclofen depressed the dorsal root reflex. The excitability of the motoneurone was reduced by CS-722 and eperisone. Excitability of the primary afferent fibres was reduced by CS-722, while eperisone and baclofen had no effect. Both CS-722 and eperisone did not have a depressant influence on the focal synaptic potential. These results suggest that CS-722 and eperisone but not baclofen, have a common motoneurone-membrane-stabilizing action and that this action may contribute, in part, to the spinal reflex depressant effects of CS-722 and eperisone.lld:pubmed
pubmed-article:1436401pubmed:languageenglld:pubmed
pubmed-article:1436401pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1436401pubmed:citationSubsetIMlld:pubmed
pubmed-article:1436401pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1436401pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1436401pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1436401pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1436401pubmed:statusMEDLINElld:pubmed
pubmed-article:1436401pubmed:monthSeplld:pubmed
pubmed-article:1436401pubmed:issn0028-3908lld:pubmed
pubmed-article:1436401pubmed:authorpubmed-author:TanabeMMlld:pubmed
pubmed-article:1436401pubmed:authorpubmed-author:IwataNNlld:pubmed
pubmed-article:1436401pubmed:authorpubmed-author:KanekoTTlld:pubmed
pubmed-article:1436401pubmed:authorpubmed-author:TonohiroTTlld:pubmed
pubmed-article:1436401pubmed:issnTypePrintlld:pubmed
pubmed-article:1436401pubmed:volume31lld:pubmed
pubmed-article:1436401pubmed:ownerNLMlld:pubmed
pubmed-article:1436401pubmed:authorsCompleteYlld:pubmed
pubmed-article:1436401pubmed:pagination949-54lld:pubmed
pubmed-article:1436401pubmed:dateRevised2003-11-14lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:meshHeadingpubmed-meshheading:1436401-...lld:pubmed
pubmed-article:1436401pubmed:year1992lld:pubmed
pubmed-article:1436401pubmed:articleTitleMechanisms of spinal reflex depressant effects of CS-722, a newly synthesized centrally acting muscle relaxant, in spinal rats.lld:pubmed
pubmed-article:1436401pubmed:affiliationNew Lead Research Laboratories, Sankyo Co. Ltd, Tokyo, Japan.lld:pubmed
pubmed-article:1436401pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1436401lld:pubmed