| pubmed-article:1436038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C0035736 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C0999967 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C0016925 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1436038 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1436038 | pubmed:issue | 6397 | lld:pubmed |
| pubmed-article:1436038 | pubmed:dateCreated | 1992-11-27 | lld:pubmed |
| pubmed-article:1436038 | pubmed:abstractText | Double-stranded RNA viruses have an RNA-dependent RNA polymerase activity associated with the viral particles which is indispensable for their replication cycle. Using the yeast L-A double-stranded RNA virus we have investigated the mechanism by which the virus encapsidates its genomic RNA and RNA polymerase. The L-A gag gene encodes the principal viral coat protein and the overlapping pol gene is expressed as a gag-pol fusion protein which is formed by a -1 ribosomal frameshift. Here we show that Gag alone is sufficient for virus particle formation, but that it fails to package the viral single-stranded RNA genome. Encapsidation of the viral RNA requires only a part of the Pol region (the N-terminal quarter), which is presumably distinct from the RNA polymerase domain. Given that the Pol region has single-stranded RNA-binding activity, these results are consistent with our L-A virus encapsidation model: the Pol region of the fusion protein binds specifically to the viral genome (+) strand, and the N-terminal gag-encoded region primes polymerization of Gag to form the capsid, thus ensuring the packaging of both the viral genome and the RNA polymerase. | lld:pubmed |
| pubmed-article:1436038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1436038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1436038 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1436038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1436038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1436038 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1436038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1436038 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1436038 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1436038 | pubmed:author | pubmed-author:RibasJ CJC | lld:pubmed |
| pubmed-article:1436038 | pubmed:author | pubmed-author:WicknerR BRB | lld:pubmed |
| pubmed-article:1436038 | pubmed:author | pubmed-author:MakhovA MAM | lld:pubmed |
| pubmed-article:1436038 | pubmed:author | pubmed-author:FujimuraTT | lld:pubmed |
| pubmed-article:1436038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1436038 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:1436038 | pubmed:volume | 359 | lld:pubmed |
| pubmed-article:1436038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1436038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1436038 | pubmed:pagination | 746-9 | lld:pubmed |
| pubmed-article:1436038 | pubmed:dateRevised | 2001-11-13 | lld:pubmed |
| pubmed-article:1436038 | pubmed:meshHeading | pubmed-meshheading:1436038-... | lld:pubmed |
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| pubmed-article:1436038 | pubmed:meshHeading | pubmed-meshheading:1436038-... | lld:pubmed |
| pubmed-article:1436038 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1436038 | pubmed:articleTitle | Pol of gag-pol fusion protein required for encapsidation of viral RNA of yeast L-A virus. | lld:pubmed |
| pubmed-article:1436038 | pubmed:affiliation | Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Spain. | lld:pubmed |
| pubmed-article:1436038 | pubmed:publicationType | Journal Article | lld:pubmed |
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