Linked Life Data

1429847

Source:http://linkedlifedata.com/resource/pubmed/id/1429847

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pubmed-article:1429847pubmed:abstractTextUsing MG-63 cells as a model system capable of partial osteoblastic differentiation, we have examined the effect of growth on extracellular matrix. MG-63 cell matrix and purified type I collagen induced a morphological change characterized by long cytoplasmic processes reminiscent of those seen in osteocytes. Concurrent biochemical changes involving bone marker proteins included increased specific activity of cell-associated alkaline phosphatase and increased secretion of osteonectin (up to 2.5-fold for each protein); all changes occurred without alterations in the growth kinetics of the MG-63 cells. The increase in alkaline phosphatase activity was maximal on days 6-8 following seeding; increased osteonectin secretion was most prominent immediately following seeding; all changes decreased as cells reached confluence. Growing cells on type I collagen resulted in an increased induction of alkaline phosphatase activity by 1,25(OH)2D3 (with little change in the 1,25(OH)2D3 induction of osteonectin and osteocalcin secretion), and increased TGF-beta induction of alkaline phosphatase activity as well (both TGF-beta 1 and TGF-beta 2). Both the 1,25(OH)2D3 and TGF-beta effects appeared to be synergistic with growth on type I collagen. These studies support the hypothesis that bone extracellular matrix may play an important role in osteoblastic differentiation and phenotypic expression.lld:pubmed
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pubmed-article:1429847pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1429847pubmed:articleTitleGrowth on type I collagen promotes expression of the osteoblastic phenotype in human osteosarcoma MG-63 cells.lld:pubmed
pubmed-article:1429847pubmed:affiliationDepartment of Biochemistry, University of Vermont, Burlington 05405.lld:pubmed
pubmed-article:1429847pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1429847pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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