| pubmed-article:1424666 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0033808 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0022568 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0040341 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0332237 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C1522168 | lld:lifeskim |
| pubmed-article:1424666 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:1424666 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1424666 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1424666 | pubmed:abstractText | Treatment of bacterial keratitis requires frequent application of topical antibiotics. We studied the efficacy of a single topical administration of tobramycin incorporated in large multivesicular liposomes and enmeshed in a fibrin sealant on rabbit corneas infected with Pseudomonas aeruginosa. One cornea each of 25 New Zealand albino rabbits was infected with P. aeruginosa. Twenty-four hours later, the animals were randomly divided into five groups of five. Group A received single hourly drops (50 microliters) of fortified tobramycin (14.5 mg/ml, total of 17.4 mg). Group B received a single topical application of 3.5 mg tobramycin, in 0.1 ml multivesicular liposomes, enmeshed in a fibrin sealant with an overlaying bandage contact lens. Group C was treated in the same manner as group B without the addition of fibrin sealant. Groups D and E served as nondrug-treated controls, with group D receiving topical fibrin-enmeshed liposomes devoid of tobramycin and group E receiving hourly topical balanced salt solution (BSS) drops. All animals were killed 24 h after initiation of therapy. Significantly fewer colonies of Pseudomonas were present in corneas of all three treated groups, as compared with the two nondrug-treated control groups (p less than 0.02). There were significantly fewer colonies of Pseudomonas in groups A and B as compared with group C (p less than 0.02). No significant difference was noted between a single administration of topical fibrinen-meshed tobramycin-encapsulated liposomes (group B) and 24 doses of hourly fortified topical tobramycin (group A, p greater than 0.05). Tobramycin-encapsulated megaliposomes may serve as a useful adjunct in treatment of Pseudomonas keratitis. | lld:pubmed |
| pubmed-article:1424666 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1424666 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424666 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1424666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424666 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1424666 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1424666 | pubmed:issn | 0277-3740 | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:ZieglerEE | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:SchanzlinD... | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:DouglasHH | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:BrownS ISI | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:AstinJ KJK | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:WeinrebR NRN | lld:pubmed |
| pubmed-article:1424666 | pubmed:author | pubmed-author:Frucht-PerryJ... | lld:pubmed |
| pubmed-article:1424666 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1424666 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1424666 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1424666 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1424666 | pubmed:pagination | 393-7 | lld:pubmed |
| pubmed-article:1424666 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:meshHeading | pubmed-meshheading:1424666-... | lld:pubmed |
| pubmed-article:1424666 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1424666 | pubmed:articleTitle | Fibrin-enmeshed tobramycin liposomes: single application topical therapy of Pseudomonas keratitis. | lld:pubmed |
| pubmed-article:1424666 | pubmed:affiliation | Bethesda Eye Institute, Department of Ophthalmology, St. Louis University, MO 63110. | lld:pubmed |
| pubmed-article:1424666 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1424666 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1424666 | lld:pubmed |
