| pubmed-article:1424280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0007582 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0056184 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0001516 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1424280 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1424280 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1424280 | pubmed:dateCreated | 1992-12-10 | lld:pubmed |
| pubmed-article:1424280 | pubmed:abstractText | Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy donors bears CR2 in a range varying from 1.1 to 23.2% (mean 12.6%) of total CD3+ cells. T lymphocytes from nine patients with inactive SLE expressed CR2 in a similar range. Three patients with active SLE were also studied. One of them, having neuropathy and glomerulonephritis, displayed an expansion of the CR2 T cell subpopulation which reached as much as 89% of total CD3+ cells. To examine potential functional roles of T cell CR2, cells from a Jurkat-derived CR2 expressing T cell line were found to bind in vitro to human CR2-, complement-coated K562 cell targets in a CR2- and complement-dependent fashion. Based on these studies, we hypothesize that CR2 might act to increase adherence of T cells to nucleated target cells bearing C3d,g, a function which may be relevant to cytotoxicity or other T cell activities requiring cell-cell interaction. | lld:pubmed |
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| pubmed-article:1424280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1424280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1424280 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1424280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1424280 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1424280 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:LevyEE | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:KahnJJ | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:MolinaHH | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:AmbrusJJ | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:TungKK | lld:pubmed |
| pubmed-article:1424280 | pubmed:author | pubmed-author:HolersV MVM | lld:pubmed |
| pubmed-article:1424280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1424280 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:1424280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1424280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1424280 | pubmed:pagination | 235-44 | lld:pubmed |
| pubmed-article:1424280 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1424280 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1424280 | pubmed:articleTitle | T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE). | lld:pubmed |
| pubmed-article:1424280 | pubmed:affiliation | Howard Hughes Medical Institute Laboratories, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110. | lld:pubmed |
| pubmed-article:1424280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1424280 | pubmed:publicationType | In Vitro | lld:pubmed |
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