| pubmed-article:1408764 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1408764 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:1408764 | lifeskim:mentions | umls-concept:C0085104 | lld:lifeskim |
| pubmed-article:1408764 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1408764 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1408764 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:1408764 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:1408764 | pubmed:dateCreated | 1992-10-30 | lld:pubmed |
| pubmed-article:1408764 | pubmed:abstractText | Inhibition of gene expression by antisense oligonucleotides is limited by their low ability to enter cells. Knowing that sugar binding receptors, also called membrane lectins, efficiently internalize neoglycoproteins bearing the relevant sugar, 6-phosphomannose, for instance, oligonucleotides--substituted on their 5'-end with either a fluorescent probe or a radioactive label on the one hand, and bearing a thiol function on their 3'-end, on the other hand,--were coupled onto 6-phosphomannosylated proteins via a disulfide bridge. The oligonucleotide bound to 6-phosphomannosylated serum albumin is much more efficiently internalized roughly 20 times than the free oligonucleotide. Although most of the oligonucleotides are associated with vesicular compartments, oligonucleotides after releasing from the carrier by reduction of the disulfide bridge may find their way to reach the cytosol and then lead to an increase in the efficiency of the oligonucleotides. | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1408764 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1408764 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1408764 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1408764 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:MonsignyMM | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:RocheA CAC | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:ThuongN TNT | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:MidouxPP | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:BonfilsEE | lld:pubmed |
| pubmed-article:1408764 | pubmed:author | pubmed-author:DepierreuxCC | lld:pubmed |
| pubmed-article:1408764 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1408764 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1408764 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1408764 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1408764 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1408764 | pubmed:pagination | 4621-9 | lld:pubmed |
| pubmed-article:1408764 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
| pubmed-article:1408764 | pubmed:meshHeading | pubmed-meshheading:1408764-... | lld:pubmed |
