| pubmed-article:1406664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0600466 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C1709313 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1406664 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1406664 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1406664 | pubmed:dateCreated | 1992-11-16 | lld:pubmed |
| pubmed-article:1406664 | pubmed:abstractText | The retinoic acid-induced differentiation of F9 cells into parietal endoderm-like cells activates transcription of the endogenous mouse retrovirus, the intracisternal A-particle (IAP). To investigate the elements that control IAP gene differentiation-specific expression, we used methylation interference, Southwestern (DNA-protein), and transient-transfection assays and identified the IAP-proximal enhancer (IPE) element that directs differentiation-specific expression. We find that the IPE is inactive in undifferentiated F9 cells and active in differentiated parietal endoderm-like PYS-2 cells. Three proteins of 40, 60, and 68 kDa bind to the sequence GAGTAGAC located between nucleotides -53 and -47 within the IPE. The 40- and 68-kDa proteins from both the undifferentiated and differentiated cells exhibit similar DNA-binding activities. However, the 60-kDa protein from differentiated cells has greater binding activity than that from undifferentiated cells, suggesting a role for this protein in F9 differentiation-specific expression of the IAP gene. The IAP gene is negatively regulated by the adenovirus E1A proteins, and the E1A sequence responsible for repression is located at the N terminus, between amino acids 2 and 67. The DNA sequence that is the target of E1A repression also maps to the IPE element. Colocalization of the differentiation-specific and E1A-sensitive elements to the same protein-binding site within the IPE suggests that the E1A-like activity functions in F9 cells to repress IAP gene expression. Activation of the IAP gene may result when the E1A-like activity is lost or inactivated during F9 cell differentiation, followed by binding of the 60-kDa positive regulatory protein to the enhancer element. | lld:pubmed |
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| pubmed-article:1406664 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1406664 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1406664 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1406664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1406664 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1406664 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:SolterDD | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:HoweC CCC | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:WeinmannRR | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:NeriRR | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:BasuAA | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:XuM QMQ | lld:pubmed |
| pubmed-article:1406664 | pubmed:author | pubmed-author:SatyamoorthyK... | lld:pubmed |
| pubmed-article:1406664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1406664 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1406664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1406664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1406664 | pubmed:pagination | 4824-33 | lld:pubmed |
| pubmed-article:1406664 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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