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pubmed-article:1390944pubmed:abstractTextHb Rouen (alpha 140(HC2) Tyr-->His) is a moderately high oxygen-affinity variant that was found in coincidence with polycythemia vera in a French patient. This hemoglobin provides an example of an alteration of the C-terminus of the alpha-chain, a region involved in the mechanisms of allosteric regulation. The increase in oxygen-affinity and decrease in cooperativity of this variant is much smaller than that resulting from the same substitution in the beta-chain. This model provides additional evidence for the inequivalence between the alpha- and beta-subunits.lld:pubmed
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pubmed-article:1390944pubmed:articleTitleHemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity.lld:pubmed
pubmed-article:1390944pubmed:affiliationINSERM U299, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.lld:pubmed
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