| pubmed-article:1390917 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0015525 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:1390917 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:1390917 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1390917 | pubmed:dateCreated | 1992-11-16 | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:abstractText | The guinea-pig and human Hageman factors differ in their sensitivity to activation by particular bacterial proteinases. To understand this difference, the primary structure and cleavage site on activation of the guinea-pig molecule were determined and compared with the human molecule. By the use of a synthetic oligodeoxyribonucleotide probe which encoded a part of human Hageman factor cDNA, a cDNA clone was isolated from a lambda gt11 cDNA library of guinea-pig liver and sequenced. The cDNA clone was identified as that of guinea-pig Hageman factor by the complete identity of the deduced amino-acid sequence with the actual sequence of the amino-terminal portion of guinea-pig Hageman factor molecule and the active form. The cDNA included part of a leader sequence and the entire coding region of the Hageman factor molecule. Guinea-pig Hageman factor was composed of the same domain structures as the human counterpart with an overall 72% homology in the amino-acid sequence. However, the sequences around the cleavage site were surprisingly different; -Met351-Thr-Arg-Val-Val-Gly-Gly-Leu-Val359-(human) and -Leu338-Ser-Arg-Ile-Val-Gly-Gly-Leu-Val346-(guinea-pig). The amino-acid substitutions around the cleavage site might explain the difference in sensitivity to activation between the human and guinea-pig molecules. | lld:pubmed |
| pubmed-article:1390917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1390917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1390917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1390917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1390917 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1390917 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:OkabeHH | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:YamamotoTT | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:KambaraTT | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:TanaseSS | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:SemanGG | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:ShibuyaYY | lld:pubmed |
| pubmed-article:1390917 | pubmed:author | pubmed-author:KunisadaTT | lld:pubmed |
| pubmed-article:1390917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1390917 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:1390917 | pubmed:volume | 1159 | lld:pubmed |
| pubmed-article:1390917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1390917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1390917 | pubmed:pagination | 113-21 | lld:pubmed |
| pubmed-article:1390917 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:meshHeading | pubmed-meshheading:1390917-... | lld:pubmed |
| pubmed-article:1390917 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1390917 | pubmed:articleTitle | Primary structure of guinea-pig Hageman factor: sequence around the cleavage site differs from the human molecule. | lld:pubmed |
| pubmed-article:1390917 | pubmed:affiliation | Department of Laboratory Medicine, School of Medicine, Kumamoto University, Japan. | lld:pubmed |
| pubmed-article:1390917 | pubmed:publicationType | Journal Article | lld:pubmed |
