| pubmed-article:1389486 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C0007427 | lld:lifeskim |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C0200765 | lld:lifeskim |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:1389486 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:1389486 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1389486 | pubmed:dateCreated | 1992-11-3 | lld:pubmed |
| pubmed-article:1389486 | pubmed:abstractText | Cathepsin-D (cath-D) was quantified in 34 breast cancer specimens by immunohistochemical staining of frozen sections with a computer image analysis and the results were compared with the corresponding cytosolic assay. Cath-D concentrations varied from 0 to 420 arbitrary units (AU). Tumour cells were more intensely stained than peritumoral tissue with the D7E3 mouse monoclonal antibody than with rabbit polyclonal antibodies. There was a good correlation (r = 0.80) between cath-D values obtained either by immunohistochemistry with D7E3 antibody or by cytosolic immunoenzymatic assay. However, with a cut-off of 50 AU, 3 out of 25 patients had higher immunohistochemical values and 2 had higher cytosolic values. Therefore, quantification of cath-D concentration in tissue section by immunostaining and a computerised image analyser, which is the only technique available for small tumours, should provide similar prognostic information to that obtained by assaying cath-D in the cytosol. | lld:pubmed |
| pubmed-article:1389486 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1389486 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1389486 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1389486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1389486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1389486 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1389486 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1389486 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:RochefortHH | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:RogerPP | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:PagesAA | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:MaudelondeTT | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:BrouilletJ... | lld:pubmed |
| pubmed-article:1389486 | pubmed:author | pubmed-author:GiraudierVV | lld:pubmed |
| pubmed-article:1389486 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1389486 | pubmed:volume | 28A | lld:pubmed |
| pubmed-article:1389486 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1389486 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1389486 | pubmed:pagination | 1686-91 | lld:pubmed |
| pubmed-article:1389486 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:meshHeading | pubmed-meshheading:1389486-... | lld:pubmed |
| pubmed-article:1389486 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1389486 | pubmed:articleTitle | Immunostaining of cathepsin D in breast cancer: quantification by computerised image analysis and correlation with cytosolic assay. | lld:pubmed |
| pubmed-article:1389486 | pubmed:affiliation | Unité INSERM 148 Hormones and Cancer, Montpellier, France. | lld:pubmed |
| pubmed-article:1389486 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1389486 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1389486 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1389486 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1389486 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1389486 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1389486 | lld:pubmed |
