| pubmed-article:1385111 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0016026 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C1517880 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:1385111 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:1385111 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1385111 | pubmed:dateCreated | 1992-12-18 | lld:pubmed |
| pubmed-article:1385111 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:abstractText | Fibroblast growth factor (FGF) receptor (FGFR) gene family consists of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation. Here we have characterized the binding of different FGFs to FGFR-4. Our results establish an FGF binding profile for FGFR-4 with aFGF having the highest affinity, followed by K-FGF/hst-1 and bFGF. In addition, FGF-6 was found to bind to FGFR-4 in ligand competition experiments. Interestingly, the FGFR-4 gene was found to encode only the prototype receptor in a region where both FGFR-1 and FGFR-2 show alternative splicing leading to differences in their ligand binding specificities and to secreted forms of these receptors. Ligands binding to FGFR-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides, which differed from those phosphorylated in FGFR-1-expressing cells. Specifically, the FGFR-1-expressing cells showed a considerably more extensive tyrosine phosphorylation of PLC-gamma than the FGFR-4-expressing cells. Structural and functional specificity within the FGFR family exemplified by FGFR-4 may help to explain how FGFs perform their diverse functions. | lld:pubmed |
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| pubmed-article:1385111 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1385111 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1385111 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1385111 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1385111 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:BirnbaumDD | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:BasilicoCC | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:PartanenJJ | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:AlitaloKK | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:JayeMM | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:VainikkaSS | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:CoulierFF | lld:pubmed |
| pubmed-article:1385111 | pubmed:author | pubmed-author:BellostaPP | lld:pubmed |
| pubmed-article:1385111 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1385111 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1385111 | pubmed:geneSymbol | FGFR | lld:pubmed |
| pubmed-article:1385111 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1385111 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1385111 | pubmed:pagination | 4273-80 | lld:pubmed |
| pubmed-article:1385111 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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