Linked Life Data

1382106

Source:http://linkedlifedata.com/resource/pubmed/id/1382106

Statements in which the resource exists.
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pubmed-article:1382106pubmed:abstractTextHematopoietic progenitor (CD34+) cells were purified from the bone marrow of 6 human immunodeficiency virus (HIV) type 1-seropositive cytopenic patients and 10 healthy donors. HIV-1-seropositive patients showed a reduced number of granulocyte/macrophage, erythroid, and megakaryocyte progenitors and also a progressive and significant decline of numbers of CD34+ cells in liquid culture, which did not result from a productive or latent HIV-1 infection of CD34+ cells. However, all HIV-1-seropositive patients showed signs of active viral replication at the bone marrow level. Moreover, virus isolates from 3 HIV-1-seropositive patients showed a dose-dependent inhibition on growth of normal CD34+ cells. This suppressive activity was almost completely reversed by incubating the virus isolates with an anti-gp120 polyclonal antibody before adding to normal CD34+ cells.lld:pubmed
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pubmed-article:1382106pubmed:articleTitleEvidence for a human immunodeficiency virus type 1-mediated suppression of uninfected hematopoietic (CD34+) cells in AIDS patients.lld:pubmed
pubmed-article:1382106pubmed:affiliationInstitutes of Microbiology and Hematology (L and A Seragnoli), University of Bologna, Italy.lld:pubmed
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