| pubmed-article:1380488 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1380488 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:1380488 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:1380488 | lifeskim:mentions | umls-concept:C0001349 | lld:lifeskim |
| pubmed-article:1380488 | lifeskim:mentions | umls-concept:C0209548 | lld:lifeskim |
| pubmed-article:1380488 | pubmed:dateCreated | 1992-9-24 | lld:pubmed |
| pubmed-article:1380488 | pubmed:abstractText | NF-IL6 was originally identified as a DNA-binding protein responsible for IL-1-stimulated IL-6 induction. Direct cloning of NF-IL6 revealed its homology with C/EBP. C/EBP is expressed in liver and adipose tissues and is supposed to regulate several hepatocyte- and adipocyte-specific genes. In contrast, NF-IL6 is suppressed in normal tissues, but is rapidly and drastically induced by LPS or inflammatory cytokines such as IL-1, TNF, and IL-6. NF-IL6 can also bind to the regulatory region of various genes including IL-8, G-CSF, IL-1 and immunoglobulin genes. Furthermore, NF-IL6 is shown to be identical to IL-6DBP, a DNA-binding protein responsible for IL-6-mediated induction in acute-phase proteins, demonstrating that NF-IL6 is responsible for the genes regulated by IL-6. These results indicate that NF-IL6 may be a pleiotropic mediator of many inducible genes involved in acute, immune, and inflammatory responses, like NFkB. In this regard, it is noteworthy that both an NF-IL6 binding site and an NFkB binding site are present in the inducible genes such as IL-6, IL-8, and several acute-phase genes. On the other hand, accumulating evidence has revealed that overproduction of IL-6 may be responsible for the pathogenesis and/or several symptoms of a variety of diseases, including autoimmune diseases, malignancies, and viral diseases. At present, the molecular mechanisms of abnormal expression of the IL-6 gene are not known. Recently it has become evident that interplays between viral proteins and cellular proteins play an important role in viral oncogenesis and infection. The fact that NF-IL6 binds to the enhancer core sequences of various viruses strongly suggests a possible relationship of virus infection and IL-6 expression. In fact some evidence (Mahe et al. 1991, Spergel et al. 1992) indicates that NF-IL6 may interact with viral gene enhancers or viral products, although there are no definite data about the involvement of NF-IL6 in viral pathogenesis. Future studies will be required to clarify whether or not the interplay between NF-IL6 and viral infection is responsible for deregulation of the IL-6 gene. | lld:pubmed |
| pubmed-article:1380488 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1380488 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1380488 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1380488 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1380488 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1380488 | pubmed:issn | 0105-2896 | lld:pubmed |
| pubmed-article:1380488 | pubmed:author | pubmed-author:KishimotoTT | lld:pubmed |
| pubmed-article:1380488 | pubmed:author | pubmed-author:AkiraSS | lld:pubmed |
| pubmed-article:1380488 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1380488 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:1380488 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1380488 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1380488 | pubmed:pagination | 25-50 | lld:pubmed |
| pubmed-article:1380488 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:1380488 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1380488 | pubmed:articleTitle | IL-6 and NF-IL6 in acute-phase response and viral infection. | lld:pubmed |
| pubmed-article:1380488 | pubmed:affiliation | Institute for Molecular and Cellular Biology, Osaka University, Japan. | lld:pubmed |
| pubmed-article:1380488 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1380488 | pubmed:publicationType | Review | lld:pubmed |
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