Linked Life Data

1379596

Source:http://linkedlifedata.com/resource/pubmed/id/1379596

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1379596rdf:typepubmed:Citationlld:pubmed
pubmed-article:1379596lifeskim:mentionsumls-concept:C0680022lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0242275lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0858252lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C2752508lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1179435lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1167322lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0074477lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0009017lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1705248lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1548799lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1524073lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C1883220lld:lifeskim
pubmed-article:1379596lifeskim:mentionsumls-concept:C0449432lld:lifeskim
pubmed-article:1379596pubmed:issue23lld:pubmed
pubmed-article:1379596pubmed:dateCreated1992-9-10lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:databankReferencehttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:abstractTextAscites sublines of the 13762 rat mammary adenocarcinoma have a cell surface sialomucin complex composed of the sialomucin ascites sialoglycoprotein-1 (ASGP-1) and the membrane-associated glycoprotein ASGP-2. The sialomucin complex is synthesized as a high M(r) precursor, pre-sialomucin complex (pSMC-1). To characterize the structure of the membrane-associated component of this complex, a lambda gt11 cDNA expression library was constructed using mRNA from 13762 rat mammary adenocarcinoma cells and screened with polyclonal antibody against ASGP-2. The strongest antibody-binding clone, designated lambda ASGP2.9-1, had a 1.3-kilobase (kb) insert, and hybridized to a 9-kb transcript in 13762 cell mRNA. The large size of this transcript was expected, since the estimated molecular mass of pSMC-1 is greater than 250 kDa. To obtain the full sequence of ASGP-2, a longer cDNA (5.4 kb), designated pASGP1/2.1, was subsequently cloned by screening a plasmid library with an oligonucleotide complementary to the 5' end of the phage insert. The amino acid sequence derived from nucleotide sequence of pASGP1/2.1 showed a 12-amino acid identity with amino acid sequence obtained from the NH2 terminus of ASGP-2, indicating the entire ASGP-2 coding region was included in the cDNA. Furthermore, an 18-amino acid identity with the NH2 terminus of a 6-kDa CNBr fragment of ASGP-2 was also observed in the cDNA sequence. The polypeptide contains several distinct domains, including a hydrophobic transmembrane domain, a short (20 residue) COOH-terminal cytoplasmic tail, and a large extracellular domain with 24 potential N-glycosylation sites. These properties correspond to features of ASGP-2 and pSMC-1 predicted by previous biochemical studies. Most interestingly, the extracellular domain contains two cysteine-rich sequences, each of which has a segment with strong similarities to proteins with epidermal growth factor activity. Since our recent studies show that ASGP-2 can modulate epidermal growth factor receptor phosphorylation activity, these results provide structural evidence to support the role of the heterodimeric sialomucin complex as a bifunctional modulator of cellular interactions and cell proliferation.lld:pubmed
pubmed-article:1379596pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:languageenglld:pubmed
pubmed-article:1379596pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:citationSubsetIMlld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1379596pubmed:statusMEDLINElld:pubmed
pubmed-article:1379596pubmed:monthAuglld:pubmed
pubmed-article:1379596pubmed:issn0021-9258lld:pubmed
pubmed-article:1379596pubmed:authorpubmed-author:CarrawayK LKLlld:pubmed
pubmed-article:1379596pubmed:authorpubmed-author:WuKKlld:pubmed
pubmed-article:1379596pubmed:authorpubmed-author:ShengZZlld:pubmed
pubmed-article:1379596pubmed:authorpubmed-author:FregienNNlld:pubmed
pubmed-article:1379596pubmed:issnTypePrintlld:pubmed
pubmed-article:1379596pubmed:day15lld:pubmed
pubmed-article:1379596pubmed:volume267lld:pubmed
pubmed-article:1379596pubmed:ownerNLMlld:pubmed
pubmed-article:1379596pubmed:authorsCompleteYlld:pubmed
pubmed-article:1379596pubmed:pagination16341-6lld:pubmed
pubmed-article:1379596pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:meshHeadingpubmed-meshheading:1379596-...lld:pubmed
pubmed-article:1379596pubmed:year1992lld:pubmed
pubmed-article:1379596pubmed:articleTitleMolecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily.lld:pubmed
pubmed-article:1379596pubmed:affiliationDepartment of Molecular Biology and Biochemistry, University of Miami School of Medicine, Florida 33101.lld:pubmed
pubmed-article:1379596pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1379596pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:1379596pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
entrez-gene:303887entrezgene:pubmedpubmed-article:1379596lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:1379596lld:pubmed
More...