| pubmed-article:1376561 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0010803 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1376561 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1376561 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1376561 | pubmed:dateCreated | 1992-7-13 | lld:pubmed |
| pubmed-article:1376561 | pubmed:abstractText | MCF-10A, a spontaneously immortalized human breast epithelial cell line, has been transformed by transfection with the mutated c-Ha-ras oncogene obtained from T24 carcinoma cells. The pattern of cytokeratin expression was studied in MCF-10A cells in comparison with plasmid transfected or MCF-10Aneo cells, normal ras proto oncogene transfected or MCF-10AneoN cells, and transformed or MCF-10AneoT cells. Cytokeratin expression was studied by western immunoblot of total cellular proteins separated by two-dimensional gel electrophoresis. Blots with cytokeratin specific AE1 and AE3 antibodies showed identical molecular weight species of cytokeratins in MCF-10A, MCF-10Aneo, MCF-10AneoN, and MCF-10AneoT cells; however, in MCF-10AneoT cells, the intensity of immunostaining and the number of immunoreactive phosphorylated polypeptides keratins 7, 8, 15, and 16 was decreased. It was concluded that c-Ha-ras oncogene-induced transformation alters quantitatively the cytokeratin pattern of human breast epithelial cells and that these changes could explain some of the morphologic alterations observed in c-Ha-ras transformed cells. | lld:pubmed |
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| pubmed-article:1376561 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1376561 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1376561 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1376561 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1376561 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1376561 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:RussoJJ | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:BasoloFF | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:GeronimiCC | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:ElliottJ WJW | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:FontaniniGG | lld:pubmed |
| pubmed-article:1376561 | pubmed:author | pubmed-author:PaineT MTM | lld:pubmed |
| pubmed-article:1376561 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1376561 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:1376561 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1376561 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1376561 | pubmed:pagination | 1483-8 | lld:pubmed |
| pubmed-article:1376561 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
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| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
| pubmed-article:1376561 | pubmed:meshHeading | pubmed-meshheading:1376561-... | lld:pubmed |
| pubmed-article:1376561 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1376561 | pubmed:articleTitle | Mutated c-Ha-ras oncogene alters cytokeratin expression in the human breast epithelial cell line MCF-10A. | lld:pubmed |
| pubmed-article:1376561 | pubmed:affiliation | Michigan Cancer Foundation, Detroit. | lld:pubmed |
| pubmed-article:1376561 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1376561 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1376561 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1376561 | lld:pubmed |
