| pubmed-article:1374903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0400914 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0014441 | lld:lifeskim |
| pubmed-article:1374903 | lifeskim:mentions | umls-concept:C0597551 | lld:lifeskim |
| pubmed-article:1374903 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1374903 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
| pubmed-article:1374903 | pubmed:abstractText | An enzyme-linked immunosorbent assay (ELISA) was developed by using a synthetic polypeptide (SP) whose sequence was derived from the structural region of hepatitis C virus (HCV). Results of several coded panels of sera obtained from volunteer blood donors and patients with apparent non-A, non-B hepatitis and/or hepatitis B virus used in this ELISA were compared with those of a commercially available first-generation C-100 ELISA (using nonstructural HCV antigens), an experimental second-generation C-200/C-22 ELISA (using both structural and nonstructural HCV antigens), and recombinant immunoblot assays RIBA-I and RIBA-II. In the majority of cases, the results obtained with the HCV-SP ELISA correlated well with those obtained by RIBA-II and C-200/C-22 ELISA. In contrast, many samples that were repeatedly reactive in the C-100 ELISA results were nonreactive with RIBA and HCV-SP ELISA. In addition, HCV-SP detected HCV-specific antibody that appeared within a month of infection and coincided with the earliest increase in alanine aminotransferase. In summary, we have developed an ELISA based on a structural HCV synthetic polypeptide, HCV-SP, that has high specificity and sensitivity and is capable of detecting specific antibodies in the acute phase of HCV infection. | lld:pubmed |
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| pubmed-article:1374903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1374903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1374903 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1374903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1374903 | pubmed:month | May | lld:pubmed |
| pubmed-article:1374903 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:HollandP VPV | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:SchiffG MGM | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:BaroudyB MBM | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:ZeldisJ BJB | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:KuramotoI KIK | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:KotwalG JGJ | lld:pubmed |
| pubmed-article:1374903 | pubmed:author | pubmed-author:McDonaldF FFF | lld:pubmed |
| pubmed-article:1374903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1374903 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1374903 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1374903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1374903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1374903 | pubmed:pagination | 4486-9 | lld:pubmed |
| pubmed-article:1374903 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1374903 | pubmed:meshHeading | pubmed-meshheading:1374903-... | lld:pubmed |
| pubmed-article:1374903 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1374903 | pubmed:articleTitle | Detection of acute hepatitis C virus infection by ELISA using a synthetic peptide comprising a structural epitope. | lld:pubmed |
| pubmed-article:1374903 | pubmed:affiliation | Division of Molecular Virology, James N. Gamble Institute of Medical Research, Cincinnati, OH 45219. | lld:pubmed |
| pubmed-article:1374903 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1374903 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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