| pubmed-article:1374861 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0005768 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0013313 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0005847 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0040408 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1374861 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:1374861 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1374861 | pubmed:dateCreated | 1992-6-12 | lld:pubmed |
| pubmed-article:1374861 | pubmed:abstractText | We investigated the effects of unilateral electrical trigeminal ganglion stimulation (0.1 or 1.0 mA, 5 Hz, 5 ms, 5 min) on the morphology of blood vessels within the rat dura mater and tongue using light and transmission electron microscopy. Stimulation at both intensities caused changes which were confined to the ipsilateral post-capillary venules except in the tongue where arterioles were affected as well. Changes were more marked after 1.0 mA. Dramatic increases in the numbers of endothelial pinocytotic vesicles were found along the luminal and abluminal surfaces ipsilateral to the stimulation. Tight junctions remained largely intact, except that injected ferritin particles were occasionally trapped inside these junctions. Cytoplasmic microvilli and endothelial blebs were sometimes present as well. Approximately 80% of the examined dural post-capillary venules showed one or more of these endothelial changes. Horseradish peroxidase injected intravenously 5 min prior to stimulation was detected in the extracellular space surrounding dural blood vessels and within pinocytotic vesicles. Ferritin injected similarly, was also localized in post-capillary venule walls, interstitial spaces, intraendothelial vesicles and in vacuoles. Platelet accumulation and aggregation were present in approximately 10% of post-capillary venules in dura and tongue. These changes were associated with mast cell secretion, but neither vascular nor mast cell activation was observed in adult rats in whom C-fibers were destroyed during the neonatal period with capsaicin. The present observations provide morphological evidence which supports findings from previously reported albumin tracer studies suggesting enhanced transport and endothelial activation following electrical stimulation of small caliber afferent fibers. | lld:pubmed |
| pubmed-article:1374861 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1374861 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1374861 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1374861 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1374861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1374861 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1374861 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:1374861 | pubmed:author | pubmed-author:MoskowitzM... | lld:pubmed |
| pubmed-article:1374861 | pubmed:author | pubmed-author:TheoharidesT... | lld:pubmed |
| pubmed-article:1374861 | pubmed:author | pubmed-author:DimitriadouVV | lld:pubmed |
| pubmed-article:1374861 | pubmed:author | pubmed-author:BuzziM GMG | lld:pubmed |
| pubmed-article:1374861 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1374861 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:1374861 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1374861 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1374861 | pubmed:pagination | 187-203 | lld:pubmed |
| pubmed-article:1374861 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1374861 | pubmed:meshHeading | pubmed-meshheading:1374861-... | lld:pubmed |
| pubmed-article:1374861 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1374861 | pubmed:articleTitle | Ultrastructural evidence for neurogenically mediated changes in blood vessels of the rat dura mater and tongue following antidromic trigeminal stimulation. | lld:pubmed |
| pubmed-article:1374861 | pubmed:affiliation | Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111. | lld:pubmed |
| pubmed-article:1374861 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1374861 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1374861 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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