| pubmed-article:1374232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C1708096 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C0599844 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C0871935 | lld:lifeskim |
| pubmed-article:1374232 | lifeskim:mentions | umls-concept:C0651293 | lld:lifeskim |
| pubmed-article:1374232 | pubmed:dateCreated | 1992-6-2 | lld:pubmed |
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| pubmed-article:1374232 | pubmed:abstractText | Using solid-phase methods we have synthesized human insulin-like-growth-factor-I (IGF-I) fragment 21-40 (IGF-I 21-40) and the peptide derived from the 5'----3' translation of the complementary nucleic acid of this peptide, 'I-FGI 20-40' (the complementary peptide). According to a recently proposed theory of molecular recognition, these two peptides should bind specifically to each other. We have tested this theory by using both solid- and solution-phase direct-binding assays for this complementary-peptide pair. We have also investigated the ability of I-FGI 20-40 to interfere with native IGF-I binding during radioimmunoassay (r.i.a.), radio-receptor (r.r.a.) assay and ligand-blot analysis of IGF-binding proteins. We have obtained no evidence of any interaction between IGF-I 21-40 and I-FGI 20-40 in either solid- or solution-phase assays. In addition, I-FGI 20-40 does not interfere in the assays used to detect IGF-I binding antibodies (r.i.a.), receptors (r.r.a.) or binding proteins (ligand blots). Our data therefore question the universality of this particular theory of molecular recognition. | lld:pubmed |
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| pubmed-article:1374232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1374232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1374232 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1374232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1374232 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1374232 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1374232 | pubmed:author | pubmed-author:FlintD JDJ | lld:pubmed |
| pubmed-article:1374232 | pubmed:author | pubmed-author:BeattieJJ | lld:pubmed |
| pubmed-article:1374232 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1374232 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1374232 | pubmed:volume | 283 ( Pt 2) | lld:pubmed |
| pubmed-article:1374232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1374232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1374232 | pubmed:pagination | 473-8 | lld:pubmed |
| pubmed-article:1374232 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1374232 | pubmed:meshHeading | pubmed-meshheading:1374232-... | lld:pubmed |
| pubmed-article:1374232 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1374232 | pubmed:articleTitle | Critical evaluation of a theory of molecular recognition using human insulin-like-growth-factor-I fragment 21-40 and its complementary peptide. | lld:pubmed |
