| pubmed-article:1371355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C0041221 | lld:lifeskim |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1371355 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:1371355 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1371355 | pubmed:dateCreated | 1992-3-23 | lld:pubmed |
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| pubmed-article:1371355 | pubmed:abstractText | A gene sequence encoding an immunodominant protein with a repetitive epitope from the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, was cloned and expressed. The identified 10-amino acid repeat is present within a high-molecular-weight trypomastigote antigen that appears specific to and conserved among T. cruzi isolates. More importantly, greater than 95% of T. cruzi infection sera, including both chronic and acute Chagas disease, contained elevated levels of antibody to a 15-amino acid synthetic peptide bearing the repetitive B-cell epitope. Considering the wide diversity of T. cruzi parasites, as well as the broad spectrum of clinical manifestations of Chagas disease, such a prevalent immune response among patients is significant and applicable to the control of Chagas disease through the diagnosis of T. cruzi infection. | lld:pubmed |
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| pubmed-article:1371355 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1371355 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1371355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1371355 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1371355 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:ReedS GSG | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:MarchC JCJ | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:SleathP RPR | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:BurnsJ MJMJr | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:ShrefflerW... | lld:pubmed |
| pubmed-article:1371355 | pubmed:author | pubmed-author:RosmanD EDE | lld:pubmed |
| pubmed-article:1371355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1371355 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1371355 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1371355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1371355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1371355 | pubmed:pagination | 1239-43 | lld:pubmed |
| pubmed-article:1371355 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1371355 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1371355 | pubmed:articleTitle | Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi. | lld:pubmed |
| pubmed-article:1371355 | pubmed:affiliation | Seattle Biomedical Research Institute, WA 98109. | lld:pubmed |
| pubmed-article:1371355 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1371355 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1371355 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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