| pubmed-article:13678441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0007303 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:13678441 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:13678441 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:13678441 | pubmed:dateCreated | 2003-9-18 | lld:pubmed |
| pubmed-article:13678441 | pubmed:abstractText | Articular cartilage biochemical composition and mechanical properties evolve during in utero and in vivo growth, with marked differences between fetus, newborn, and young adult. The objectives of this study were to test whether in vitro growth of bovine fetal and newborn calf articular cartilage explants resulted in changes in biochemical and tensile properties during up to 6 weeks of free-swelling culture in serum-supplemented medium. During this culture period, both fetal and calf cartilage grew markedly in size, increasing in dry and wet mass by 150-270%. This was due in part to increases in sulfated glycosaminoglycan (+248%), collagen (+96%), and pyridinoline cross-link (+133%). This was accompanied by an increase in water content so that the concentration of matrix components decreased, despite the overall net increase in mass. The ratio of pyridinoline cross-link to collagen remained low and characteristic of immature tissue. The equilibrium and dynamic tensile moduli and strength of both fetal and calf cartilage decreased during the culture period. The biochemical and biomechanical properties of the cartilage explants were correlated, such that the low values of modulus and strength were associated with low concentrations of collagen and pyridinoline. Thus, the tested culture conditions supported growth and maintenance cartilage in an immature state, but did not induce biomechanical or collagen network maturation. | lld:pubmed |
| pubmed-article:13678441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:13678441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:13678441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:13678441 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:13678441 | pubmed:issn | 1076-3279 | lld:pubmed |
| pubmed-article:13678441 | pubmed:author | pubmed-author:SahRobert LRL | lld:pubmed |
| pubmed-article:13678441 | pubmed:author | pubmed-author:MasudaKoichiK | lld:pubmed |
| pubmed-article:13678441 | pubmed:author | pubmed-author:ThonarEugene... | lld:pubmed |
| pubmed-article:13678441 | pubmed:author | pubmed-author:WilliamsonAma... | lld:pubmed |
| pubmed-article:13678441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:13678441 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:13678441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:13678441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:13678441 | pubmed:pagination | 625-34 | lld:pubmed |
| pubmed-article:13678441 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:meshHeading | pubmed-meshheading:13678441... | lld:pubmed |
| pubmed-article:13678441 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:13678441 | pubmed:articleTitle | Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties. | lld:pubmed |
| pubmed-article:13678441 | pubmed:affiliation | Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA. | lld:pubmed |
| pubmed-article:13678441 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:13678441 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:13678441 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:13678441 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:13678441 | lld:pubmed |
