| pubmed-article:13678408 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0040048 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0079017 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0005036 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0015505 | lld:lifeskim |
| pubmed-article:13678408 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:13678408 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:13678408 | pubmed:dateCreated | 2003-9-18 | lld:pubmed |
| pubmed-article:13678408 | pubmed:abstractText | Several multistep syntheses of substituted benzenes are reported. The benzene analogues were designed such that their substitution pattern would occupy and interact with the S(1), S(2), and S(3) pockets of the tissue Factor VIIa enzyme. A variety of chemical transformations including nucleophilic additions, reductive aminations, Stille couplings, and polymer-assisted solution-phase (PASP) techniques were used to prepare key intermediates and final products. The initial analogues identified some weakly active compounds which ultimately led to a 340 nM (IC(50)) tissue Factor VIIa inhibitor with selectivity over other related enzymes. The structure-activity relationship of these inhibitors and the synthetic progression from the discovery of the lead compound to the development of potent analogues will be discussed. The X-ray crystal structures of fluorobenzene 50c and benzoquinone 54 inhibitors complexed with the TF/VIIa enzyme will also be described. | lld:pubmed |
| pubmed-article:13678408 | pubmed:language | eng | lld:pubmed |
| pubmed-article:13678408 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:13678408 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:13678408 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:13678408 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:StallingsWill... | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:StevensAnna... | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:KurumbailRavi... | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:SouthMichael... | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:StegemanRoder... | lld:pubmed |
| pubmed-article:13678408 | pubmed:author | pubmed-author:ParlowJohn... | lld:pubmed |
| pubmed-article:13678408 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:13678408 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:13678408 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:13678408 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:13678408 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:13678408 | pubmed:pagination | 4297-312 | lld:pubmed |
| pubmed-article:13678408 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:meshHeading | pubmed-meshheading:13678408... | lld:pubmed |
| pubmed-article:13678408 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:13678408 | pubmed:articleTitle | Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors. | lld:pubmed |
| pubmed-article:13678408 | pubmed:affiliation | Department of Medicinal and Combinatorial Chemistry, Pharmacia Corporation, 800 North Lindbergh Boulevard, St. Louis, Missouri 63167, USA. john.j.parlow@pfizer.com | lld:pubmed |
| pubmed-article:13678408 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:13678408 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:13678408 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:13678408 | lld:chembl |
