| pubmed-article:1365325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C1882062 | lld:lifeskim |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C0474643 | lld:lifeskim |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:1365325 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1365325 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1365325 | pubmed:dateCreated | 1995-1-24 | lld:pubmed |
| pubmed-article:1365325 | pubmed:abstractText | Reactive oxygen species (ROS) produced by phagocytic cells induce oxidative stress during chronic inflammation. ROS play a role in the pathogenesis of a broad range of diseases including autoimmune, cardiac and neoplastic abnormalities. We found that sera of patients with a variety of inflammatory dermatoses contain elevated levels of antibodies (Ab) binding to an oxidized DNA base derivative, 5-hydroxymethyl-2'deoxyuridine (HMdU) coupled to bovine serum albumin, as determined by the enzyme-linked immunosorbent assay. Patients with immune complex diseases and a history of neoplasm elaborated the highest titers of anti-HMdU Ab. Titers from sera of psoriatic subjects were lower than from the aforementioned groups but were still significantly elevated (p < 0.001) above those of healthy controls. Treatment of inflammatory dermatoses with systemic antiinflammatory and cytotoxic drugs significantly lowered the titers [p < 0.005 (immune complex) or p < 0.001 (psoriasis and neoplastic) diseases], suggesting that this assay may be of value in monitoring the response to therapy in these diseases. | lld:pubmed |
| pubmed-article:1365325 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1365325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1365325 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1365325 | pubmed:issn | 0906-6705 | lld:pubmed |
| pubmed-article:1365325 | pubmed:author | pubmed-author:FrenkelKK | lld:pubmed |
| pubmed-article:1365325 | pubmed:author | pubmed-author:StillerMM | lld:pubmed |
| pubmed-article:1365325 | pubmed:author | pubmed-author:KarkoszkaJJ | lld:pubmed |
| pubmed-article:1365325 | pubmed:author | pubmed-author:ShupackJJ | lld:pubmed |
| pubmed-article:1365325 | pubmed:author | pubmed-author:KhasanAA | lld:pubmed |
| pubmed-article:1365325 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1365325 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:1365325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1365325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1365325 | pubmed:pagination | 242-7 | lld:pubmed |
| pubmed-article:1365325 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:meshHeading | pubmed-meshheading:1365325-... | lld:pubmed |
| pubmed-article:1365325 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1365325 | pubmed:articleTitle | Enhanced antibody titers to an oxidized DNA base in inflammatory and neoplastic diseases. | lld:pubmed |
| pubmed-article:1365325 | pubmed:affiliation | Department of Environmental Medicine, New York University Medical Center, NY 10016-6451. | lld:pubmed |
| pubmed-article:1365325 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1365325 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1365325 | lld:pubmed |
