| pubmed-article:1359258 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C0027051 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C0002965 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C0014025 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C2700378 | lld:lifeskim |
| pubmed-article:1359258 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:1359258 | pubmed:issue | 8829 | lld:pubmed |
| pubmed-article:1359258 | pubmed:dateCreated | 1992-12-17 | lld:pubmed |
| pubmed-article:1359258 | pubmed:abstractText | An association between raised renin levels and myocardial infarction has been reported. We studied the effects of enalapril, an angiotensin-converting enzyme (ACE) inhibitor, on the development of myocardial infarction and unstable angina in 6797 patients with ejection fractions < or = 0.35 enrolled into the two Studies of Left Ventricular Dysfunction (SOLVD) trials. Patients were randomly assigned to placebo (n = 3401) or enalapril (n = 3396) at doses of 2.5-20 mg per day in two concurrent double-blind trials with the same protocol. Patients with heart failure entered the treatment trial (n = 2569) and those without heart failure entered the prevention trial (n = 4228). Follow-up averaged 40 months. In each trial there were significant reductions in the number of patients developing myocardial infarction (treatment trial: 158 placebo vs 127 enalapril, p < 0.02; prevention trial: 204 vs 161 p < 0.01) or unstable angina (240 vs 187 p < 0.001; 355 vs 312, p < 0.05). Combined, there were 362 placebo group patients with myocardial infarction compared with 288 in the enalapril group (risk reduction 23%, 95% CI 11-34%; p < 0.001). 595 placebo group patients developed unstable angina compared with 499 in the enalapril group (risk reduction 20%, 95% CI 9-29%, p < 0.001). There was also a reduction in cardiac deaths (711 placebo, 615 enalapril; p < 0.003), so that the reduction in the combined endpoint of deaths, myocardial infarction, and unstable angina was highly significant (20% risk reduction, 95% CI 14-26%; p < 0.0001). Enalapril treatment significantly reduced myocardial infarction, unstable angina, and cardiac mortality in patients with low ejection fractions. | lld:pubmed |
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| pubmed-article:1359258 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1359258 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1359258 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1359258 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1359258 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1359258 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1359258 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:PittBB | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:KostisJJ | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:YusufSS | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:PouleurHH | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:PepineC JCJ | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:RousseauMM | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:BourassaMM | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:BenedictCC | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:SalemDD | lld:pubmed |
| pubmed-article:1359258 | pubmed:author | pubmed-author:GarcesCC | lld:pubmed |
| pubmed-article:1359258 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1359258 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:1359258 | pubmed:volume | 340 | lld:pubmed |
| pubmed-article:1359258 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1359258 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1359258 | pubmed:pagination | 1173-8 | lld:pubmed |
| pubmed-article:1359258 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1359258 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1359258 | pubmed:articleTitle | Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. | lld:pubmed |
| pubmed-article:1359258 | pubmed:affiliation | National Heart, Lung, and Blood Institute, Bethesda, Maryland. | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:1359258 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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