| pubmed-article:1357752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C0483191 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C2347338 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1357752 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:1357752 | pubmed:issue | 5082 | lld:pubmed |
| pubmed-article:1357752 | pubmed:dateCreated | 1992-11-25 | lld:pubmed |
| pubmed-article:1357752 | pubmed:abstractText | Thymic selection of the developing T cell repertoire is thought to occur at the CD4+CD8+ stage of differentiation and to be determined by the specificity of the T cell receptors (TCRs) that CD4+CD8+ thymocytes express. However, TCR signals can inhibit the differentiation of precursor thymocytes into CD4+CD8+ cells, which suggests that selection might occur earlier than thought. Indeed, in a negatively selecting male thymus, CD4-CD8lo precursor thymocytes that express a transgenic TCR to male antigen are developmentally arrested as a consequence of antigen encounter and fail to become CD4+CD8+. Thus, negative selection can occur before the CD4+CD8+ stage of differentiation. | lld:pubmed |
| pubmed-article:1357752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1357752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1357752 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1357752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1357752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1357752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1357752 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1357752 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:1357752 | pubmed:author | pubmed-author:SingerAA | lld:pubmed |
| pubmed-article:1357752 | pubmed:author | pubmed-author:TakahamaYY | lld:pubmed |
| pubmed-article:1357752 | pubmed:author | pubmed-author:ShoresE WEW | lld:pubmed |
| pubmed-article:1357752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1357752 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:1357752 | pubmed:volume | 258 | lld:pubmed |
| pubmed-article:1357752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1357752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1357752 | pubmed:pagination | 653-6 | lld:pubmed |
| pubmed-article:1357752 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:1357752 | pubmed:meshHeading | pubmed-meshheading:1357752-... | lld:pubmed |
| pubmed-article:1357752 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1357752 | pubmed:articleTitle | Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells. | lld:pubmed |
| pubmed-article:1357752 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:1357752 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:15218 | entrezgene:pubmed | pubmed-article:1357752 | lld:entrezgene |
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