| pubmed-article:1353547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0752221 | lld:lifeskim |
| pubmed-article:1353547 | lifeskim:mentions | umls-concept:C0141409 | lld:lifeskim |
| pubmed-article:1353547 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1353547 | pubmed:dateCreated | 1992-8-31 | lld:pubmed |
| pubmed-article:1353547 | pubmed:abstractText | To study the effect of the Kampo drug Saiboku-to (TJ-96) on ion transport function of airway epithelial cells, we studied bioelectric properties of cultured tracheal epithelium from dogs under short-circuit conditions in vitro. Addition of TJ-96 (1 mg/ml) to the mucosal solution of the Ussing chamber increased the epithelial short-circuit current (SCC) from 6.5 +/- 0.7 to 11.4 +/- 1.6 microA/cm2 (P less than 0.001). This effect was dose-dependent, with the maximal increase from the baseline value and the concentration required to produce a half-maximal effect (EC50) being 70.5 +/- 12.6% (P less than 0.001) and 3 micrograms/ml, respectively; and there were corresponding increases in transepithelial potential difference and cell conductance. Submucosal addition of TJ-96 likewise increased SCC, although the magnitude of the response was smaller as compared with the response to the mucosal addition. The TJ-96-induced increase in SCC was not affected by diphenylamine-2-carboxylate or furosemide but abolished by amiloride. Intracellular cyclic AMP levels were dose-dependently increased by TJ-96. These results indicate that TJ-96 may selectively stimulate Na absorption across the tracheal epithelium, probably through intracellular accumulation of cyclic AMP. | lld:pubmed |
| pubmed-article:1353547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1353547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1353547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1353547 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1353547 | pubmed:issn | 0021-5198 | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:KonnoKK | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:SakaiNN | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:TakizawaTT | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:TakeyamaKK | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:TamaokiJJ | lld:pubmed |
| pubmed-article:1353547 | pubmed:author | pubmed-author:ChiyotaniAA | lld:pubmed |
| pubmed-article:1353547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1353547 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:1353547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1353547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1353547 | pubmed:pagination | 47-53 | lld:pubmed |
| pubmed-article:1353547 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
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| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:meshHeading | pubmed-meshheading:1353547-... | lld:pubmed |
| pubmed-article:1353547 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1353547 | pubmed:articleTitle | Stimulation of Na absorption by the antiasthmatic kampo drug Saiboku-to in cultured airway epithelium. | lld:pubmed |
| pubmed-article:1353547 | pubmed:affiliation | First Department of Medicine, Tokyo Women's Medical College, Japan. | lld:pubmed |
| pubmed-article:1353547 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1353547 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
