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pubmed-article:1353351pubmed:abstractTextWe examined the effect of chronic treatment with ethanol on the dynamics of beta-adrenoceptor binding in left ventricular myocardium of rats. After treatment with BAAM (20 mg/kg i.p.), an irreversible inhibitor of beta-adrenoceptors, the inhibition of beta-adrenoceptor binding was less, and the recovery of receptor binding was faster in chronically ethanol-treated rats compared to the control animals given equicaloric dextrin maltose treatment. When intracellular beta-adrenoceptor recycling was inhibited with colchicine, cytoplasmic left ventricular beta-adrenoceptor binding was greater in ethanol-treated compared to dextrin maltose-treated animals. We conclude that the previously reported decreased functional activity of the beta-adrenoceptor-mediated system probably reflects the contribution of ethanol-mediated effects not entirely restricted to the receptor-binding mechanisms.lld:pubmed
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pubmed-article:1353351pubmed:articleTitleChronic ethanol treatment of rats and the myocardial beta-adrenoceptors.lld:pubmed
pubmed-article:1353351pubmed:affiliationCenter of Alcohol Studies, Rutgers University, Piscataway, NJ 08854.lld:pubmed
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