Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:1352085rdf:typepubmed:Citationlld:pubmed
pubmed-article:1352085lifeskim:mentionsumls-concept:C0040162lld:lifeskim
pubmed-article:1352085lifeskim:mentionsumls-concept:C1882810lld:lifeskim
pubmed-article:1352085lifeskim:mentionsumls-concept:C0034307lld:lifeskim
pubmed-article:1352085lifeskim:mentionsumls-concept:C0072132lld:lifeskim
pubmed-article:1352085lifeskim:mentionsumls-concept:C1621967lld:lifeskim
pubmed-article:1352085lifeskim:mentionsumls-concept:C0870883lld:lifeskim
pubmed-article:1352085pubmed:issue6 Pt 1lld:pubmed
pubmed-article:1352085pubmed:dateCreated1992-7-29lld:pubmed
pubmed-article:1352085pubmed:abstractTextWe demonstrate that two enzymes, soluble unspecific pyroglutamyl peptidase I and prolyl endopeptidase, able to degrade thyrotropin-releasing hormone (TRH) in vitro were present in pancreas at the early stage of rat development. Specific particulate pyroglutamyl peptidase II remained undetectable during ontogenesis. Pyroglutamyl peptidase I specific activity increased until day 3 and decreased after day 5. Furthermore, prolyl endopeptidase specific activity rose slightly to a peak on postnatal day 20. A good correlation between immunoreactive TRH and deaminated TRH (TRH-OH) was found in the 1st wk after birth. However, His-Pro diketopiperazine (DKP) levels were stable and low during development. We show that hot acidic extraction conditions could artefactually generate His-Pro DKP. In vivo, active site-directed inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase enzymes do not show any TRH-deamidating and/or pyroglutamyl peptidase I pathways in neonatal rat pancreas. The data suggest that these two enzymes are not involved in intra- or extracellular control of TRH levels in neonatal rat pancreas and that pancreatic TRH content appears to be principally regulated by biosynthetic steps. Nevertheless, low levels of endogenous His-Pro DKP and TRH-OH identified in neonatal rat pancreas suggest that TRH or TRH-like peptides may be metabolized in this tissue in intact rats, albeit at low rates.lld:pubmed
pubmed-article:1352085pubmed:languageenglld:pubmed
pubmed-article:1352085pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:citationSubsetIMlld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:1352085pubmed:statusMEDLINElld:pubmed
pubmed-article:1352085pubmed:monthJunlld:pubmed
pubmed-article:1352085pubmed:issn0002-9513lld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:OliverCClld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:GiraudPPlld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:SalersPPlld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:DutourAAlld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:OuafikL HLHlld:pubmed
pubmed-article:1352085pubmed:authorpubmed-author:MalteseJ YJYlld:pubmed
pubmed-article:1352085pubmed:issnTypePrintlld:pubmed
pubmed-article:1352085pubmed:volume262lld:pubmed
pubmed-article:1352085pubmed:ownerNLMlld:pubmed
pubmed-article:1352085pubmed:authorsCompleteYlld:pubmed
pubmed-article:1352085pubmed:paginationE845-50lld:pubmed
pubmed-article:1352085pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:meshHeadingpubmed-meshheading:1352085-...lld:pubmed
pubmed-article:1352085pubmed:year1992lld:pubmed
pubmed-article:1352085pubmed:articleTitleOntogeny of prolyl endopeptidase, pyroglutamyl peptidase I, TRH, and its metabolites in rat pancreas.lld:pubmed
pubmed-article:1352085pubmed:affiliationLaboratoire de Neuroendocrinologie Experimentale, Institut National de la Santé et de la Recherche Médicale U297, Faculté de Médecine Nord, Marseille, France.lld:pubmed
pubmed-article:1352085pubmed:publicationTypeJournal Articlelld:pubmed