pubmed-article:1352085 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C0040162 | lld:lifeskim |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C1882810 | lld:lifeskim |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C0034307 | lld:lifeskim |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C0072132 | lld:lifeskim |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C1621967 | lld:lifeskim |
pubmed-article:1352085 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
pubmed-article:1352085 | pubmed:issue | 6 Pt 1 | lld:pubmed |
pubmed-article:1352085 | pubmed:dateCreated | 1992-7-29 | lld:pubmed |
pubmed-article:1352085 | pubmed:abstractText | We demonstrate that two enzymes, soluble unspecific pyroglutamyl peptidase I and prolyl endopeptidase, able to degrade thyrotropin-releasing hormone (TRH) in vitro were present in pancreas at the early stage of rat development. Specific particulate pyroglutamyl peptidase II remained undetectable during ontogenesis. Pyroglutamyl peptidase I specific activity increased until day 3 and decreased after day 5. Furthermore, prolyl endopeptidase specific activity rose slightly to a peak on postnatal day 20. A good correlation between immunoreactive TRH and deaminated TRH (TRH-OH) was found in the 1st wk after birth. However, His-Pro diketopiperazine (DKP) levels were stable and low during development. We show that hot acidic extraction conditions could artefactually generate His-Pro DKP. In vivo, active site-directed inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase enzymes do not show any TRH-deamidating and/or pyroglutamyl peptidase I pathways in neonatal rat pancreas. The data suggest that these two enzymes are not involved in intra- or extracellular control of TRH levels in neonatal rat pancreas and that pancreatic TRH content appears to be principally regulated by biosynthetic steps. Nevertheless, low levels of endogenous His-Pro DKP and TRH-OH identified in neonatal rat pancreas suggest that TRH or TRH-like peptides may be metabolized in this tissue in intact rats, albeit at low rates. | lld:pubmed |
pubmed-article:1352085 | pubmed:language | eng | lld:pubmed |
pubmed-article:1352085 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1352085 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1352085 | pubmed:month | Jun | lld:pubmed |
pubmed-article:1352085 | pubmed:issn | 0002-9513 | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:OliverCC | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:GiraudPP | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:SalersPP | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:DutourAA | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:OuafikL HLH | lld:pubmed |
pubmed-article:1352085 | pubmed:author | pubmed-author:MalteseJ YJY | lld:pubmed |
pubmed-article:1352085 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1352085 | pubmed:volume | 262 | lld:pubmed |
pubmed-article:1352085 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1352085 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1352085 | pubmed:pagination | E845-50 | lld:pubmed |
pubmed-article:1352085 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:1352085 | pubmed:year | 1992 | lld:pubmed |
pubmed-article:1352085 | pubmed:articleTitle | Ontogeny of prolyl endopeptidase, pyroglutamyl peptidase I, TRH, and its metabolites in rat pancreas. | lld:pubmed |
pubmed-article:1352085 | pubmed:affiliation | Laboratoire de Neuroendocrinologie Experimentale, Institut National de la Santé et de la Recherche Médicale U297, Faculté de Médecine Nord, Marseille, France. | lld:pubmed |
pubmed-article:1352085 | pubmed:publicationType | Journal Article | lld:pubmed |