| pubmed-article:1349325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0026626 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0025918 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C1881878 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0439806 | lld:lifeskim |
| pubmed-article:1349325 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:1349325 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1349325 | pubmed:dateCreated | 1992-6-2 | lld:pubmed |
| pubmed-article:1349325 | pubmed:abstractText | Previously we reported that as AKR.H-2b:Fv-1b mice become older than 9 wk of age they begin to specifically lose the ability to generate anti-AKR/Gross murine leukemia virus (MuLV) CTL responses after immunization and in vitro restimulation with cells expressing AKR/Gross MuLV-encoded Ag. Interestingly, the frequency of virus-specific precursor cytotoxic T lymphocytes (CTL) observed in moderately-aged AKR.H-2b:Fv-1b mice was not substantially decreased from that found in their young responder counterparts. To further investigate the mechanism(s) responsible for the inability of moderately-aged AKR.H-2b:Fv-1b mice to mount AKR/Gross MuLV-specific CTL responses, adoptive transfer experiments were performed in the present study. Transferring splenocytes from moderately-aged AKR.H-2b:Fv-1b donors into young AKR.H-2b:Fv-1b recipients resulted in inhibition of AKR/Gross MuLV-specific CTL responsiveness. Anti-Thy-1.1 plus complement depletion of T cells from the donor cell population before adoptive transfer resulted in a near complete restoration of AKR/Gross MuLV responsiveness of young recipient AKR.H-2b:Fv-1b mice suggesting that the inhibition observed in moderately aged mice was mediated by T lymphocytes. Additional experiments using depletion of T subsets before cell transfer demonstrated that inhibition of AKR/Gross MuLV-specific CTL responsiveness was mediated by a CD4-CD8+ T lymphocyte. | lld:pubmed |
| pubmed-article:1349325 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1349325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1349325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1349325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1349325 | pubmed:month | May | lld:pubmed |
| pubmed-article:1349325 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1349325 | pubmed:author | pubmed-author:FujiiTT | lld:pubmed |
| pubmed-article:1349325 | pubmed:author | pubmed-author:GreenW RWR | lld:pubmed |
| pubmed-article:1349325 | pubmed:author | pubmed-author:RichR FRF | lld:pubmed |
| pubmed-article:1349325 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1349325 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1349325 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1349325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1349325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1349325 | pubmed:pagination | 2961-7 | lld:pubmed |
| pubmed-article:1349325 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
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| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:meshHeading | pubmed-meshheading:1349325-... | lld:pubmed |
| pubmed-article:1349325 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1349325 | pubmed:articleTitle | CD4-CD8+ T lymphocytes mediate AKR/gross murine leukemia virus nonresponsiveness in moderately aged AKR.H-2b:Fv-1b mice. | lld:pubmed |
| pubmed-article:1349325 | pubmed:affiliation | Department of Microbiology, Dartmouth Medical School, Hanover, NH 03756. | lld:pubmed |
| pubmed-article:1349325 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1349325 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1349325 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1349325 | lld:pubmed |
