| pubmed-article:1348547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1348547 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1348547 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1348547 | pubmed:dateCreated | 1992-5-14 | lld:pubmed |
| pubmed-article:1348547 | pubmed:abstractText | In order to clarify the protective immune responses against a newly identified herpesvirus, human herpesvirus 6 (HHV-6), we established HHV-6-specific human T-cell clones and examined their functional properties. Five CD3+CD4+CD8- T-cell clones, which proliferated in response to stimulation with two different strains of HHV-6 in the presence of autologous antigen-presenting cells but not with herpes simplex virus type 1 or human cytomegalovirus, were established from peripheral blood lymphocytes of a healthy individual. The proliferative response of all T-cell clones to HHV-6 antigen was inhibited by addition of anti-HLA-DR monoclonal antibody, indicating that these clones were human leukocyte antigen (HLA) class II DR restricted. Of the five clones, two lysed HHV-6-infected autologous lymphoblasts, but not HHV-6-infected allogeneic cells or natural killer-sensitive K562 cells (group 1); one showed cytotoxicity against HHV-6-infected autologous lymphoblasts as well as HHV-6-infected allogeneic cells and K562 cells (group 2); and the remaining two showed no cytotoxic activity (group 3). The cytotoxic activity of group 1 was inhibited by addition of anti-HLA-DR monoclonal antibody to the culture, whereas this monoclonal antibody had no effect on the cytotoxicity of group 2 and did not induce the cytotoxicity of group 3. Perforin, which is one of the mediators of cytotoxicity, was abundantly expressed in group 1 and 2 clones. Moreover, all groups of clones produced gamma interferon after culture with antigen-presenting cells followed by HHV-6 antigen stimulation. These results suggest that HHV-6-specific CD4+ T cells have heterogeneous functions. | lld:pubmed |
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| pubmed-article:1348547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1348547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1348547 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1348547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1348547 | pubmed:month | May | lld:pubmed |
| pubmed-article:1348547 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1348547 | pubmed:author | pubmed-author:KobayashiYY | lld:pubmed |
| pubmed-article:1348547 | pubmed:author | pubmed-author:YasukawaMM | lld:pubmed |
| pubmed-article:1348547 | pubmed:author | pubmed-author:YakushijinYY | lld:pubmed |
| pubmed-article:1348547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1348547 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1348547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1348547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1348547 | pubmed:pagination | 2773-9 | lld:pubmed |
| pubmed-article:1348547 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1348547 | pubmed:meshHeading | pubmed-meshheading:1348547-... | lld:pubmed |
| pubmed-article:1348547 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1348547 | pubmed:articleTitle | Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones. | lld:pubmed |
| pubmed-article:1348547 | pubmed:affiliation | First Department of Internal Medicine, Ehime University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:1348547 | pubmed:publicationType | Journal Article | lld:pubmed |
