| pubmed-article:1347493 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0040149 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0677607 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0085247 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0483191 | lld:lifeskim |
| pubmed-article:1347493 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:1347493 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1347493 | pubmed:dateCreated | 1992-4-13 | lld:pubmed |
| pubmed-article:1347493 | pubmed:abstractText | We examined peripheral lymphocyte subsets in patients with autoimmune thyroid disease, or subacute thyroiditis, in the active stage when possible. During destructive thyrotoxicosis arising from alpha beta T cell receptor (TCR) negative T (WT31-CD3+) cells and CD8 (CD4-CD8+) cells decreased and those of CD4+CD8+ cells increased slightly, resulting in proportional increases in CD4 (CD4+CD8-) cells, non-T, non-B (CD5-CD19-) cells, and the CD4/CD8 cell ratio. Changes were similar in active subacute thyroiditis. During stimulative thyrotoxicosis in active Graves' disease, the numbers of such T lymphocyte subsets were not changed, but only the number of CD5+ B (CD5+CD19+) cells increased markedly, resulting in proportional decreases in total T (CD3+) cells, alpha beta+ TCR T (WT31+CD3+) cells, CD8 cells, and non-T, non-B cells. A serial study of some of the patients showed opposite changes in alpha beta TCR- T cells, the CD4/CD8 cell ratio, and CD5+ B cells between the active stages of Graves' and Hashimoto's diseases. alpha beta TCR- T cells were mostly gamma delta TCR+ T (IIF2+ CD3+) cells in these patients. These data suggest that alpha beta TCR-T (gamma delta TCR+ T), CD8, and CD4+ CD8+ cells are important in thyroid destruction in Hashimoto's disease and subacute thyroiditis, and that CD5+ B cells are important in thyroid stimulation in Graves' disease. | lld:pubmed |
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| pubmed-article:1347493 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1347493 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347493 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1347493 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1347493 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1347493 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:TamakiHH | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:IchiharaKK | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:MiyaiKK | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:AminoNN | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:KumaKK | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:KanedaTT | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:MatsuzukaFF | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:HidakaYY | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:IwataniYY | lld:pubmed |
| pubmed-article:1347493 | pubmed:author | pubmed-author:FukataSS | lld:pubmed |
| pubmed-article:1347493 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1347493 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:1347493 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1347493 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1347493 | pubmed:pagination | 444-9 | lld:pubmed |
| pubmed-article:1347493 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1347493 | pubmed:meshHeading | pubmed-meshheading:1347493-... | lld:pubmed |
| pubmed-article:1347493 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1347493 | pubmed:articleTitle | Decreases in alpha beta T cell receptor negative T cells and CD8 cells, and an increase in CD4+ CD8+ cells in active Hashimoto's disease and subacute thyroiditis. | lld:pubmed |
| pubmed-article:1347493 | pubmed:affiliation | Department of Laboratory Medicine, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:1347493 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1347493 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1347493 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
