| pubmed-article:1347305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:1347305 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1347305 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1347305 | pubmed:dateCreated | 1992-4-9 | lld:pubmed |
| pubmed-article:1347305 | pubmed:abstractText | IL-4 production by T lymphocytes from naive mice in response to stimulation by plate-bound anti-CD3 is concentrated among CD4+ T cells. In vitro stimulation of lymph node T cells with anti-CD3 plus IL-2 and IL-4 strikingly increases the frequency of cells that produce IL-4 in response to subsequent stimulation with anti-CD3 plus IL-2. Separation of these primed cell populations into CD4+ and CD8+ T cell by cell sorting reveals that the frequency of IL-4-producing cells in both population is similar. Verification that CD8+ T cells produce IL-4 is provided by the capacity of anti-IL-4 mAb to inhibit the response of the indicator cell line to the growth factor produced by the primed cells and by detection of IL-4 by an IL-4-specific ELISA. The in vitro "priming" of CD8+ T cells to produce IL-4 is not dependent on the presence of CD4+ T cells because highly purified CD8+ T cells can be stimulated to develop into cells capable of producing IL-4 by culture with plate-bound anti-CD3 plus IL-2 and IL-4. | lld:pubmed |
| pubmed-article:1347305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1347305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347305 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1347305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1347305 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1347305 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:PaulW EWE | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:Ben-SassonS... | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:FinkelmanFF | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:SederR ARA | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:BarbierSS | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:Le GrosGG | lld:pubmed |
| pubmed-article:1347305 | pubmed:author | pubmed-author:BoulayJ LJL | lld:pubmed |
| pubmed-article:1347305 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1347305 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1347305 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1347305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1347305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1347305 | pubmed:pagination | 1652-6 | lld:pubmed |
| pubmed-article:1347305 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1347305 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1347305 | pubmed:articleTitle | CD8+ T cells can be primed in vitro to produce IL-4. | lld:pubmed |
| pubmed-article:1347305 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:1347305 | pubmed:publicationType | Journal Article | lld:pubmed |
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