| pubmed-article:1332493 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0001480 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0300926 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1332493 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1332493 | pubmed:issue | 5 Pt 1 | lld:pubmed |
| pubmed-article:1332493 | pubmed:dateCreated | 1992-12-23 | lld:pubmed |
| pubmed-article:1332493 | pubmed:abstractText | Activation of protein kinase C (PKC) modulates the mobilization of intracellular Ca2+ induced by extracellular ATP in rat ventricular myocytes. Pretreatment of myocytes with PKC activators attenuated both the ATP-induced Ca2+ transient and the noradrenergic potentiation of the Ca2+ response. Various PKC activators decreased both the basal cAMP level and the cAMP levels that had been elevated by norepinephrine, forskolin, or 3-isobutyl-1-methylxanthine. The inhibitory effects of PKC activators were reversed by the PKC inhibitor staurosporine. The ATP-induced Ca2+ response is an integrated response resulting from ATP eliciting an inward cation current (IATP), cellular depolarization, Ca2+ influx through Ca2+ channels, and Ca2+ release from the sarcoplasmic reticulum. We used the whole cell voltage-clamp technique to investigate which steps of this integrated response are affected by PKC. PKC activators did not significantly affect the IATP. In contrast, PKC activators decreased the basal Ca2+ current (ICa) or Ba2+ current and the beta-adrenergic-stimulated ICa. These results suggest that PKC-induced suppression of the ATP-induced Ca2+ response and the beta-adrenergic-potentiated Ca2+ response is achieved at least partially by decreasing the intracellular cAMP level and ICa. | lld:pubmed |
| pubmed-article:1332493 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1332493 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1332493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1332493 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1332493 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1332493 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1332493 | pubmed:author | pubmed-author:ScarpaAA | lld:pubmed |
| pubmed-article:1332493 | pubmed:author | pubmed-author:LevyM NMN | lld:pubmed |
| pubmed-article:1332493 | pubmed:author | pubmed-author:ChristieAA | lld:pubmed |
| pubmed-article:1332493 | pubmed:author | pubmed-author:ZhengJ SJS | lld:pubmed |
| pubmed-article:1332493 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1332493 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:1332493 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1332493 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1332493 | pubmed:pagination | C933-40 | lld:pubmed |
| pubmed-article:1332493 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:meshHeading | pubmed-meshheading:1332493-... | lld:pubmed |
| pubmed-article:1332493 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1332493 | pubmed:articleTitle | Ca2+ mobilization by extracellular ATP in rat cardiac myocytes: regulation by protein kinase C and A. | lld:pubmed |
| pubmed-article:1332493 | pubmed:affiliation | Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106. | lld:pubmed |
| pubmed-article:1332493 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1332493 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1332493 | lld:pubmed |
