| pubmed-article:1328463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C1335268 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0020204 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C1448177 | lld:lifeskim |
| pubmed-article:1328463 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1328463 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1328463 | pubmed:dateCreated | 1992-11-2 | lld:pubmed |
| pubmed-article:1328463 | pubmed:abstractText | We investigated the biological role of the human tumor necrosis factor p75 (hTNF-R75), making use of the species specificity of TNF responses in murine (m) T cell lines. Several TNF-mediated activities on mouse T cells, such as cytokine induction or proliferation, showed a 100-500-fold difference in specific biological activity between mTNF and hTNF. After transfection of hTNF-R75 cDNA in a rat/mouse T cell hybridoma (PC60), however, the 100-fold lower specific biological activity of hTNF was converted to the same specific biological activity as mTNF. The TNF-mediated induction of granulocyte/macrophage colony-stimulating factor was strongly synergized by the addition of interleukin 1. In the presence of the latter cytokine, ligand-competing monoclonal antibodies against hTNF-R75 (utr-1, utr-2, utr-3) were agonistic on transfected PC60 cells. This agonistic activity was further enhanced by crosslinking with sheep anti-murine immunoglobulin antibodies. These data provide direct evidence for a functional role of TNF-R75, without ligand-dependent TNF-R55 involvement, in the induction of cytokine secretion in T cells. | lld:pubmed |
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| pubmed-article:1328463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1328463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1328463 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1328463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1328463 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1328463 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:FiersWW | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:GrootenJJ | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:BrockhausMM | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:LesslauerWW | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:LoetscherHH | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:VandenabeeleP... | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:DeclercqWW | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:VercammenDD | lld:pubmed |
| pubmed-article:1328463 | pubmed:author | pubmed-author:Van de... | lld:pubmed |
| pubmed-article:1328463 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1328463 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1328463 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:1328463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1328463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1328463 | pubmed:pagination | 1015-24 | lld:pubmed |
| pubmed-article:1328463 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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