| pubmed-article:1327609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0231241 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0557980 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0013331 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0074559 | lld:lifeskim |
| pubmed-article:1327609 | lifeskim:mentions | umls-concept:C0142340 | lld:lifeskim |
| pubmed-article:1327609 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1327609 | pubmed:dateCreated | 1992-11-18 | lld:pubmed |
| pubmed-article:1327609 | pubmed:abstractText | In a multicenter study we selected 84 patients with fluctuating Parkinson's disease in order to evaluate the effects of controlled-release Sinemet 50/200 (=CR) versus standard Sinemet 25/100 (=STD) in an open-label 8-week titration period, followed by a double-blind, double-dummy 24-week treatment period. In contrast with previous double-blind studies, the efficacy of Sinemet CR proved to be significantly superior to that of Sinemet-STD according to NYUPDS and NUDS rating scales. This higher efficacy of Sinemet CR was not achieved at the expense of safety and/or tolerability. Actual total daily levodopa dosage in patients treated with Sinemet CR was increased by 33%; however, the plasma level of this dosage is calculated to be similar to that of the previous dosage of Sinemet-STD (bio-availability of Sinemet CR is 71%). Mean numbers of daily doses, off-hours, and off-periods were decreased significantly during Sinemet CR treatment. Although all other variables suggest that the number of on-hours had to be increased, statistical significance could not be reached in this respect. | lld:pubmed |
| pubmed-article:1327609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1327609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1327609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1327609 | pubmed:issn | 0303-8467 | lld:pubmed |
| pubmed-article:1327609 | pubmed:author | pubmed-author:WoltersE CEC | lld:pubmed |
| pubmed-article:1327609 | pubmed:author | pubmed-author:HorstinkM WMW | lld:pubmed |
| pubmed-article:1327609 | pubmed:author | pubmed-author:JansenE NEN | lld:pubmed |
| pubmed-article:1327609 | pubmed:author | pubmed-author:ThioHH | lld:pubmed |
| pubmed-article:1327609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1327609 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:1327609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1327609 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1327609 | pubmed:pagination | 205-11 | lld:pubmed |
| pubmed-article:1327609 | pubmed:dateRevised | 2009-10-14 | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:meshHeading | pubmed-meshheading:1327609-... | lld:pubmed |
| pubmed-article:1327609 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1327609 | pubmed:articleTitle | Clinical efficacy of Sinemet CR 50/200 versus Sinemet 25/100 in patients with fluctuating Parkinson's disease. An open, and a double-blind, double-dummy, multicenter treatment evaluation. The Dutch Sinemet CR Study Group. | lld:pubmed |
| pubmed-article:1327609 | pubmed:affiliation | Department of Neurology, Free University Hospital, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:1327609 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1327609 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1327609 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1327609 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:1327609 | pubmed:publicationType | Multicenter Study | lld:pubmed |
