| pubmed-article:1327338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1327338 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1327338 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1327338 | lifeskim:mentions | umls-concept:C0016787 | lld:lifeskim |
| pubmed-article:1327338 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1327338 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:1327338 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1327338 | pubmed:dateCreated | 1992-11-6 | lld:pubmed |
| pubmed-article:1327338 | pubmed:abstractText | An established mechanism for directing newly made acid hydrolases to lysosomes involves acquisition of mannose 6-phosphate residues by the carbohydrate portion of acid hydrolases followed by binding to specific membrane-bound transport receptors and delivery to lysosomes. Two distinct phosphomannosyl receptors (CI-MPR and CD-MPR) have been identified. Alternative mechanisms for trafficking acid hydrolases exist. This report examines means for the possible receptor-mediated intracellular transport of alpha-L- fucosidase in lymphoid cells. The binding of alpha-L-fucosidase to intact cells and to total cell membrane preparations, in conjunction with immunoassays of solubilized membrane preparations, revealed the presence of CI-MPR and CD-MPR on human lymphoid and fibroblast cell lines. The mean level of CD-MPR in nine lymphoid cell lines was 7.2-fold greater than CI-MPR. The mean level of CI-MPR in two fibroblast lines was 3.8-fold greater than CD-MPR. The mean content of CI-MPR was 19.5-fold greater in the fibroblasts than in the lymphoid cells. The CD-MPR content of fibroblasts and lymphoid cells was nearly equivalent. Among these cell lines were a fibroblast and a lymphoid line from the same individual. These results indicate that human B-lymphoid cells are deficient in CI-MPR and suggest that modulation of expression of CI-MPR and CD-MPR in lymphoid cells differs from that in fibroblasts, including cell lines with identical genomes. No specific receptor capable of binding alpha-L-fucosidase independent of mannose 6-phosphate was demonstrable, despite published results that support the existence of a mannose 6-phosphate independent trafficking mechanism in lymphoid cells for this enzyme. | lld:pubmed |
| pubmed-article:1327338 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1327338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1327338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1327338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1327338 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1327338 | pubmed:issn | 0282-0080 | lld:pubmed |
| pubmed-article:1327338 | pubmed:author | pubmed-author:MillerA LAL | lld:pubmed |
| pubmed-article:1327338 | pubmed:author | pubmed-author:DicioccioR... | lld:pubmed |
| pubmed-article:1327338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1327338 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:1327338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1327338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1327338 | pubmed:pagination | 56-62 | lld:pubmed |
| pubmed-article:1327338 | pubmed:dateRevised | 2008-8-22 | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:meshHeading | pubmed-meshheading:1327338-... | lld:pubmed |
| pubmed-article:1327338 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1327338 | pubmed:articleTitle | Binding receptors for alpha-L-fucosidase in human B-lymphoid cell lines. | lld:pubmed |
| pubmed-article:1327338 | pubmed:affiliation | Department of Gynaecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263. | lld:pubmed |
| pubmed-article:1327338 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1327338 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
