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pubmed-article:1320056pubmed:abstractTextThe effect of ACTH on the expression of major histocompatibility complex (MHC) class II (I-A) glycoprotein by murine peritoneal macrophages was evaluated. ACTH suppressed the expression of I-A by macrophages in a time- and dose-dependent manner. ACTH mediated its effect by decreasing the level of I-A mRNA. ACTH suppressed the expression of I-A by macrophages from mice that are susceptible to the in vivo growth of mycobacteria but did not affect the expression of I-A by macrophages from Mycobacterium bovis strain (BCG)-resistant mice. The concentrations of ACTH required to suppress I-A expression were greater than that required for an effect on adrenal steroid production and may be related to the localized production of ACTH by lymphocytes and macrophages.lld:pubmed
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pubmed-article:1320056pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1320056pubmed:articleTitleCharacterization of ACTH mediated suppression of MHC class II expression by murine peritoneal macrophages.lld:pubmed
pubmed-article:1320056pubmed:affiliationDepartment of Microbiology, Ohio State University Columbus 43120-1292.lld:pubmed
pubmed-article:1320056pubmed:publicationTypeJournal Articlelld:pubmed
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