| pubmed-article:1318412 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0006069 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1318412 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1318412 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1318412 | pubmed:dateCreated | 1992-7-10 | lld:pubmed |
| pubmed-article:1318412 | pubmed:abstractText | The in vitro expression of bovine leukemia virus (BLV) in short-term cultured bovine peripheral blood mononuclear cells (PBMC) is associated with increased spontaneous lymphocyte blastogenesis. The purpose of this study was to determine whether intracellular pathways responsible for antigen- or mitogen-induced lymphocyte blastogenesis were also responsible for induction of BLV expression. The protein kinase C (PKC) inhibitor 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine dihydrochloride (3-methyl H7) decreased blastogenesis in a dose-dependent manner, as measured by [3H]thymidine incorporation, in unstimulated, lipopolysaccharide-stimulated and phorbol ester (PMA)-stimulated BLV-infected PBMC. Similarly, 3-methyl H7 decreased BLV expression, as measured by production of gp51 envelope antigen or p24gag antigen, in BLV-infected PBMC under the same conditions. Using an RNase protection assay, the inhibition of BLV expression by 3-methyl H7 was shown to be due to decreased transcriptional activity. The cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein kinase inhibitor N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004) did not inhibit either BLV expression or blastogenesis of BLV-infected bovine PBMC. Additional evidence for the PKC-dependent expression of BLV was obtained by using a persistently BLV-infected B-lymphocyte cell line, NBC-13. Activation of PKC by PMA in NBC-13 cells increased BLV expression. 3-methyl H7 decreased the PMA-induced expression of BLV in NBC-13 cells in a dose-dependent manner, whereas HA1004 did not inhibit this expression. These results identify a mechanism for the induction of BLV expression through PKC activation and therefore indicate that latency and replication of BLV is controlled by normal B-lymphocyte intracellular signaling pathways. | lld:pubmed |
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| pubmed-article:1318412 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1318412 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1318412 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1318412 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1318412 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1318412 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:1318412 | pubmed:author | pubmed-author:CockerellG... | lld:pubmed |
| pubmed-article:1318412 | pubmed:author | pubmed-author:JensenW AWA | lld:pubmed |
| pubmed-article:1318412 | pubmed:author | pubmed-author:Wicks-BeardB... | lld:pubmed |
| pubmed-article:1318412 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1318412 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1318412 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1318412 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1318412 | pubmed:pagination | 4427-33 | lld:pubmed |
| pubmed-article:1318412 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1318412 | pubmed:meshHeading | pubmed-meshheading:1318412-... | lld:pubmed |
| pubmed-article:1318412 | pubmed:meshHeading | pubmed-meshheading:1318412-... | lld:pubmed |
| pubmed-article:1318412 | pubmed:meshHeading | pubmed-meshheading:1318412-... | lld:pubmed |
| pubmed-article:1318412 | pubmed:meshHeading | pubmed-meshheading:1318412-... | lld:pubmed |
| pubmed-article:1318412 | pubmed:meshHeading | pubmed-meshheading:1318412-... | lld:pubmed |
