| pubmed-article:1317939 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0020268 | lld:lifeskim |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0001655 | lld:lifeskim |
| pubmed-article:1317939 | lifeskim:mentions | umls-concept:C0027481 | lld:lifeskim |
| pubmed-article:1317939 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:1317939 | pubmed:dateCreated | 1992-7-8 | lld:pubmed |
| pubmed-article:1317939 | pubmed:abstractText | Corticotrophic secretion of ACTH is stimulated by corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), and suppressed by glucocorticoids. In vitro and preclinical studies suggest that atrial natriuretic factor (ANF) may be a peptidergic inhibitor of pituitary-adrenocortical activity. The aim of this study was to elucidate a possible role of ANF as a modulator of ACTH release in humans. A bolus injection of 100 micrograms human CRH (hCRH) during a 30 min intravenous infusion of 5 micrograms/min human alpha atrial natriuretic factor (h alpha ANF) was administered at 19:00 to six healthy male volunteers. In comparison to saline, a blunted CRH-stimulated secretion of ACTH (mean maximum plasma level +/- SD 45 min after hCRH: saline 46.2 +/- 14.2 pg/ml, h alpha ANF 34.6 +/- 13.8 pg/ml, p-value = 0.007) and a delayed rise (10 min) in cortisol were detected. The maximum plasma cortisol levels remained nearly unchanged between saline and h alpha ANF administration (mean maximum plasma level +/- SD 60 min after hCRH: saline 182 +/- 26 ng/ml, h alpha ANF 166 +/- 54 ng/ml). No effects of h alpha ANF on basal cortisol levels were observed; in contrast, basal ACTH plasma levels were slightly reduced. Basal blood pressure and heart rate remained unaffected. In the control experiment, infusion of 3 IU AVP in the same experimental paradigm increased basal and stimulated ACTH and cortisol levels significantly in comparison to saline. These observations suggest that intravenously administered haANF inhibits the CRH-stimulated release of ACTH in man. | lld:pubmed |
| pubmed-article:1317939 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1317939 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1317939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1317939 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1317939 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:1317939 | pubmed:author | pubmed-author:KellnerMM | lld:pubmed |
| pubmed-article:1317939 | pubmed:author | pubmed-author:WiedemannKK | lld:pubmed |
| pubmed-article:1317939 | pubmed:author | pubmed-author:HolsboerFF | lld:pubmed |
| pubmed-article:1317939 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1317939 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:1317939 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1317939 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1317939 | pubmed:pagination | 1835-42 | lld:pubmed |
| pubmed-article:1317939 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:meshHeading | pubmed-meshheading:1317939-... | lld:pubmed |
| pubmed-article:1317939 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1317939 | pubmed:articleTitle | Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man. | lld:pubmed |
| pubmed-article:1317939 | pubmed:affiliation | Max Planck Institute of Psychiatry, Dept. of Psychiatry, Munich, Germany. | lld:pubmed |
| pubmed-article:1317939 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1317939 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1317939 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1317939 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1317939 | lld:pubmed |
