| pubmed-article:1315962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1315962 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:1315962 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:1315962 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:1315962 | lifeskim:mentions | umls-concept:C2348042 | lld:lifeskim |
| pubmed-article:1315962 | lifeskim:mentions | umls-concept:C0949906 | lld:lifeskim |
| pubmed-article:1315962 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1315962 | pubmed:dateCreated | 1992-6-5 | lld:pubmed |
| pubmed-article:1315962 | pubmed:abstractText | A guanine-rich single-stranded DNA from the human immunoglobulin switch region was shown by Sen and Gilbert [Nature, (1988) 334, 364-366] to be able to self-associate to form a stable four-stranded parallel DNA structure. Topoisomerase II did not cleave the single-stranded DNA molecule. Surprisingly, the enzyme did cleave the same DNA sequence when it was annealed into the four-stranded structure. The two cleavage sites observed were the same as those found when this DNA molecule was paired with a complementary molecule to create a normal B-DNA duplex. These cleavages were shown to be protein-linked and reversible by the addition of salt, suggesting a normal topoisomerase II reaction mechanism. In addition, an eight-stranded DNA molecule created by the association of a complementary oligonucleotide with the four-stranded structure was also cleaved by topoisomerase II despite being resistant to restriction endonuclease digestion. These results suggest that a single strand of DNA may possess the sequence information to direct topoisomerase II to a binding site, but the site must be base paired in a proper manner to do so. This demonstration of the ability of a four-stranded DNA molecule to be a substrate for an enzyme further suggests that these DNA structures may be present in cells. | lld:pubmed |
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| pubmed-article:1315962 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1315962 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1315962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1315962 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1315962 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1315962 | pubmed:author | pubmed-author:MullerM TMT | lld:pubmed |
| pubmed-article:1315962 | pubmed:author | pubmed-author:MehtaV BVB | lld:pubmed |
| pubmed-article:1315962 | pubmed:author | pubmed-author:SpitznerJ RJR | lld:pubmed |
| pubmed-article:1315962 | pubmed:author | pubmed-author:ChungI KIK | lld:pubmed |
| pubmed-article:1315962 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1315962 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1315962 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:1315962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1315962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1315962 | pubmed:pagination | 1973-7 | lld:pubmed |
| pubmed-article:1315962 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1315962 | pubmed:meshHeading | pubmed-meshheading:1315962-... | lld:pubmed |
| pubmed-article:1315962 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1315962 | pubmed:articleTitle | Eukaryotic topoisomerase II cleavage of parallel stranded DNA tetraplexes. | lld:pubmed |
| pubmed-article:1315962 | pubmed:affiliation | Department of Molecular Genetics, Ohio State University, Columbus 43210. | lld:pubmed |
| pubmed-article:1315962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1315962 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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