| pubmed-article:1315899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0680242 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0063322 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C1282913 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:1315899 | lifeskim:mentions | umls-concept:C0167813 | lld:lifeskim |
| pubmed-article:1315899 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:1315899 | pubmed:dateCreated | 1992-6-9 | lld:pubmed |
| pubmed-article:1315899 | pubmed:abstractText | The effect of 5-hydroxytryptamine (5-HT), BIMU 8 (endo-N-(8-methyl-8-azabicyclo [3.2.1.] oct-3-yl)-2,3-dihydro-3-(1-methyl)ethyl-2-oxo-1H-benzimidazole-1- carboxamide hydrochloride) and cisapride was studied on the electrically-induced neurogenic cholinergic twitch contractions in the guinea pig ileum circular muscle. These compounds caused a concentration-dependent increase in the amplitude of submaximal twitch contractions with the following rank order of potency: 5-HT greater than BIMU 8 = cisapride. The effect of 5-HT was competitively antagonized by tropisetron (ICS 205-930) (apparent pA2 value: 6.4), suggesting an interaction at 5-hydroxytryptamine4 (5-HT4) receptors. The novel benzimidazolone derivative DAU 6285 (endo-6-methoxy-8-methyl-8-azabicyclo [3.2.1.] oct-3-yl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylate hydrochloride), antagonized the effect of 5-HT, BIMU 8 and cisapride with apparent pA2 values in the range 7.1-7.3. Our findings demonstrate that cholinergic neurones innervating the circular coat are endowed with excitatory 5-HT4 receptors. DAU 6285 is approximately 5-9-fold more potent than tropisetron as antagonist at these receptors. | lld:pubmed |
| pubmed-article:1315899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1315899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1315899 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1315899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1315899 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:ManziJJ | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:ToniniMM | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:OnoriLL | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:RizziC ACA | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:CanduraS MSM | lld:pubmed |
| pubmed-article:1315899 | pubmed:author | pubmed-author:CocciniTT | lld:pubmed |
| pubmed-article:1315899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1315899 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:1315899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1315899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1315899 | pubmed:pagination | PL173-8 | lld:pubmed |
| pubmed-article:1315899 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:1315899 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1315899 | pubmed:articleTitle | 5-hydroxytryptamine4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea pig ileum: antagonism by tropisetron and DAU 6285. | lld:pubmed |
| pubmed-article:1315899 | pubmed:affiliation | Department of Internal Medicine and Therapeutics, University of Pavia, Italy. | lld:pubmed |
| pubmed-article:1315899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1315899 | pubmed:publicationType | In Vitro | lld:pubmed |
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