Catabolite gene activator protein (CAP) is not an "acidic activating region" transcription activator protein. Negatively charged amino acids of CAP that are solvent-accessible in the CAP-DNA complex play no role in transcription activation at the lac promoter.

Source:http://linkedlifedata.com/resource/pubmed/id/1314818

J. Biol. Chem. 1992 Apr 25 267 12 8136-9

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1314818