| pubmed-article:1314232 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:1314232 | lifeskim:mentions | umls-concept:C1516606 | lld:lifeskim |
| pubmed-article:1314232 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1314232 | pubmed:dateCreated | 1992-5-15 | lld:pubmed |
| pubmed-article:1314232 | pubmed:abstractText | Three cell lines derived from small-cell lung carcinoma (SCLC) tumors of patients who had no clinical response after treatment with a multi-drug regimen were compared to 3 cell lines derived from tumors of patients who, upon treatment, showed a complete clinical response. These 2 groups of cell lines were considered to represent the in vitro counterparts of the 2 extremes of the clinical spectrum of sensitivity for chemotherapeutic drugs in small-cell lung cancer. To assess whether the in vivo (in)sensitivity of a tumor to a certain drug regimen is retained in vitro, the cell lines were tested for drug sensitivity using the microtiter-well tetrazolium assay and the results were compared with the in vivo data. No correlation was found. Since in vitro models using cell lines are based on the assumption that a cell line reflects the properties of the tumor from which it is derived, several additional parameters such as MAb staining against different SCLC-associated antigens and DNA content were analyzed in the biopsies and the cell lines. The results showed that selection of discrete tumor-cell populations in vitro occurs. Results of in vitro chemosensitivity testing for individual SCLC patients should be interpreted with caution. | lld:pubmed |
| pubmed-article:1314232 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1314232 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314232 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1314232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314232 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1314232 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1314232 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1314232 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:OosterhuisJ... | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:ScheperR JRJ | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:WeeningJ JJJ | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:MulderN HNH | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:de VriesE GEG | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:de LeijL FLF | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:PostmusP EPE | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:SmitE FEF | lld:pubmed |
| pubmed-article:1314232 | pubmed:author | pubmed-author:Timmer-Bossch... | lld:pubmed |
| pubmed-article:1314232 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1314232 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:1314232 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:1314232 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1314232 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1314232 | pubmed:pagination | 72-8 | lld:pubmed |
| pubmed-article:1314232 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:meshHeading | pubmed-meshheading:1314232-... | lld:pubmed |
| pubmed-article:1314232 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1314232 | pubmed:articleTitle | In vitro response of human small-cell lung-cancer cell lines to chemotherapeutic drugs; no correlation with clinical data. | lld:pubmed |
| pubmed-article:1314232 | pubmed:affiliation | Dept. of Internal Medicine, University Hospital Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:1314232 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1314232 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1314232 | lld:pubmed |
