| pubmed-article:1312472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0079722 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0280100 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:1312472 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:1312472 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1312472 | pubmed:dateCreated | 1992-4-21 | lld:pubmed |
| pubmed-article:1312472 | pubmed:abstractText | The expression of gamma/delta T cell antigen receptors (TcR) in T cell lines or clones derived from tumor-infiltrating lymphocytes (TIL) from patients with solid tumors was investigated. gamma/delta TcR T cell lines were derived from TIL from patients with Wilms tumor, sarcoma or metastatic melanoma by stimulation with autologous tumor cells alone and recombinant interleukin 2 and they exhibited nonspecific cytotoxicity against autologous and allogeneic tumor cells, or cells of the K562 or the MEL21 tumor cell lines. Two T cell lines were derived from a patient with Wilms tumor. One of them expressed a non-disulfide-linked gamma/delta TcR using the 60-kDa gamma chain, whereas, the other expressed a disulfide-linked gamma/delta TcR. A T cell line was derived from a patient with sarcoma and expressed a disulfide-linked gamma/delta TcR, whereas, a T cell line derived from a patient with melanoma expressed a non-disulfide-linked gamma chain of 62 kDa. Several T cell clones were developed from patients with metastatic melanoma or Wilms tumor and expressed either disulfide- or non-disulfide-linked gamma/delta TcR. Northern analysis of RNA from certain of these clones revealed a full-length gamma chain transcript, whereas, the alpha or beta chain transcripts were either absent or truncated. These T cell clones exhibited nonspecific cytotoxicity. Both disulfide- and non-disulfide-linked TIL T cell lines and clones expressed the delta TCS1 determinant. gamma/delta TcR+ cells in freshly prepared TIL from these patients were present in low proportions (less than 5%) and their delta TCS1/delta 1 ratios were within the range observed in the peripheral blood of normal donors. These results demonstrate that both disulfide- and non-disulfide-linked gamma/delta TcR are expressed on T cell lines and clones derived from TIL from solid tumors. Non-disulfide-linked gamma/delta TcR using the 56-66-kDa gamma chain are frequently found on TIL-derived T cell lines and clones. These 56-66-kDa gamma chains are rarely expressed on T cell lines or clones derived from peripheral blood lymphocytes of normal donors. | lld:pubmed |
| pubmed-article:1312472 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312472 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312472 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1312472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1312472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1312472 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1312472 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:SuzukiSS | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:SekiHH | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:ItohKK | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:SuzukiRR | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:NanniGG | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:PlatsoucasC... | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:ChenP FPF | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:IoannidesC... | lld:pubmed |
| pubmed-article:1312472 | pubmed:author | pubmed-author:MathioudakisG... | lld:pubmed |
| pubmed-article:1312472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1312472 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:1312472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1312472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1312472 | pubmed:pagination | 679-87 | lld:pubmed |
| pubmed-article:1312472 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:meshHeading | pubmed-meshheading:1312472-... | lld:pubmed |
| pubmed-article:1312472 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1312472 | pubmed:articleTitle | Gamma/delta T cell antigen receptors expressed on tumor-infiltrating lymphocytes from patients with solid tumors. | lld:pubmed |
| pubmed-article:1312472 | pubmed:affiliation | Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston 77030. | lld:pubmed |
| pubmed-article:1312472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1312472 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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