| pubmed-article:1312467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C0079184 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:1312467 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1312467 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1312467 | pubmed:dateCreated | 1992-4-21 | lld:pubmed |
| pubmed-article:1312467 | pubmed:abstractText | Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human cells microinjected with anti-cyclin A antibodies at distinct times. Cyclin A binds both cdk2 and cdc2, giving two distinct cyclin A kinase activities, one appearing in S phase, the other in G2. These results suggest that cyclin A defines novel control points of the human cell cycle. | lld:pubmed |
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| pubmed-article:1312467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1312467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1312467 | pubmed:citationSubset | IM | lld:pubmed |
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