Linked Life Data

1309927

Source:http://linkedlifedata.com/resource/pubmed/id/1309927

Statements in which the resource exists.
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pubmed-article:1309927pubmed:abstractTextInbred mice with genetically determined severe combined immunodeficiency (SCID) lack mature T and B lymphocyte functions. To distinguish direct viral effects in the pathogenesis of myocarditis from those mediated by antigen-specific and histocompatibility-complex-restricted host immunity, we inoculated coxsackievirus B3 into homozygous young adult SCID mice. We found that infected SCID mice invariably developed extensive myocarditis between 7 and 14 days postinoculation with high subsequent mortality. Histopathologic examination of the infected SCID myocardium indicated multiple foci of cardiomyocyte necrosis and a delayed pleomorphic inflammatory infiltrate. Immunohistochemically, the coxsackievirus B3-infected SCID heart contained frequent clusters of macrophages (Mac-1+) as well as other cells that may represent nonspecific phagocytic or cytolytic effectors. In situ hybridization with radiolabeled cDNA probes for enteroviral genome indicated a significant excess of positive-strand genome in the SCID myocardium compared with that in similarly infected non-SCID controls, with hybridization signals localized primarily to cardiomyocytes. In vitro culture confirmed persistent viremia and a vast excess of infective virus in the SCID myocardium relative to infected non-SCID controls. Thus, direct viral mechanisms in the production of cardiomyocyte injury in coxsackievirus B3-infected mice appear to be more important than previously recognized, particularly in the setting of unrestricted viral proliferation.lld:pubmed
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pubmed-article:1309927pubmed:articleTitleEnteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury.lld:pubmed
pubmed-article:1309927pubmed:affiliationJohn P. Robarts Research Institute, University of Western Ontario, London, Canada.lld:pubmed
pubmed-article:1309927pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1309927pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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